Thu, 24 Jul 2008 15:16:57 BST CiteULike: AlfonsoVicenteSuarezs tcells-general http://www.citeulike.org/user/AlfonsoVicenteSuarez/tag/tcells-general CiteULike.org en-gb Copyright © 2004-2008 citeulike.org http://www.citeulike.org/user/AlfonsoVicenteSuarez/article/2926552 <i>Science, Vol. 309, No. 5739. (26 August 2005), pp. 1380-1384.</i><br /><br />CD4+ regulatory T (Treg) cells have a profound ability to suppress host immune responses, yet little is understood about how these cells are regulated. We describe a mechanism linking Toll-like receptor (TLR) 8 signaling to the control of Treg cell function, in which synthetic and natural ligands for human TLR8 can reverse Treg cell function. This effect was independent of dendritic cells but required functional TLR8-MyD88-IRAK4 signaling in Treg cells. Adoptive transfer of TLR8 ligand-stimulated Treg cells into tumor-bearing mice enhanced anti-tumor immunity. These results suggest that TLR8 signaling could play a critical role in controlling immune responses to cancer and other diseases. 10.1126/science.1113401 Toll-Like Receptor 8-Mediated Reversal of CD4+ Regulatory T Cell Function Guangyong Peng Zhong Guo Yukiko Kiniwa Kui Voo Weiyi Peng Tihui Fu Daniel Wang Yanchun Li Helen Wang Rong-Fu Wang doi:10.1126/science.1113401 Science, Vol. 309, No. 5739. (26 August 2005), pp. 1380-1384. 2008-06-25T17:56:55-00:00 2005 Science 309 5739 1380 1384 tcells-general t-regs http://www.citeulike.org/user/AlfonsoVicenteSuarez/article/2926544 <i>Nature, Vol. 420, No. 6915. (5 December 2002), pp. 502-507.</i> CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity Yasmine Belkaid Ciriaco Piccirillo Susana Mendez Ethan Shevach David Sacks doi:10.1038/nature01152 Nature, Vol. 420, No. 6915. (5 December 2002), pp. 502-507. 2008-06-25T17:51:22-00:00 2002 Nature 420 6915 502 507 tcells-general t-regs http://www.citeulike.org/user/AlfonsoVicenteSuarez/article/2858610 <i>Cell, Vol. 133, No. 5. (30 May 2008), pp. 775-787.</i><br /><br />Regulatory T cells (Tregs) play an indispensable role in maintaining immunological unresponsiveness to self-antigens and in suppressing excessive immune responses deleterious to the host. Tregs are produced in the thymus as a functionally mature subpopulation of T cells and can also be induced from naive T cells in the periphery. Recent research reveals the cellular and molecular basis of Treg development and function and implicates dysregulation of Tregs in immunological disease. Regulatory T cells and immune tolerance. S Sakaguchi T Yamaguchi T Nomura M Ono doi:10.1016/j.cell.2008.05.009 Cell, Vol. 133, No. 5. (30 May 2008), pp. 775-787. 2008-06-03T09:30:49-00:00 2008 Cell 1097-4172 133 5 775 787 tcells-general t-regs http://www.citeulike.org/user/AlfonsoVicenteSuarez/article/100257 <i>Science, Vol. 290, No. 5489. (6 October 2000), pp. 92-97.</i><br /><br />The immune response is initiated in organized lymphoid tissues where antigen-loaded dendritic cells (DCs) encounter antigen-specific T cells. DCs function as packets of information that must be decoded by the T cell before an appropriate immune response can be mounted. We discuss how the dynamics of DC-T cell encounter and the mechanism of T cell differentiation make the decoding of this information stochastic rather than determinate. This results in the generation of both terminally differentiated effector cells and intermediates that play distinctive roles in protection, immunoregulation, and immunological memory. Dynamics of T lymphocyte responses: intermediates, effectors, and memory cells. A Lanzavecchia F Sallusto doi:10.1126/science.290.5489.92 Science, Vol. 290, No. 5489. (6 October 2000), pp. 92-97. 2005-02-22T14:22:38-00:00 2000 Science 0036-8075 290 5489 92 97 tcells-general