Fri, 08 Aug 2008 20:05:36 BST CiteULike: AlfonsoVicenteSuarezs tlrs-general http://www.citeulike.org/user/AlfonsoVicenteSuarez/tag/tlrs-general CiteULike.org en-gb Copyright © 2004-2008 citeulike.org http://www.citeulike.org/user/AlfonsoVicenteSuarez/article/439148 <i>Nature Immunology, Vol. 7, No. 1. (11 December 2005), pp. 49-56.</i> Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA Gregory Barton Jonathan Kagan Ruslan Medzhitov doi:10.1038/ni1280 Nature Immunology, Vol. 7, No. 1. (11 December 2005), pp. 49-56. 2005-12-15T22:26:06-00:00 2005 Nature Immunology 1529-2908 7 1 49 56 Nature Publishing Group tlrs-general http://www.citeulike.org/user/AlfonsoVicenteSuarez/article/970694 <i>Cell, Vol. 124, No. 4. (24 February 2006), pp. 783-801.</i><br /><br />Microorganisms that invade a vertebrate host are initially recognized by the innate immune system through germline-encoded pattern-recognition receptors (PRRs). Several classes of PRRs, including Toll-like receptors and cytoplasmic receptors, recognize distinct microbial components and directly activate immune cells. Exposure of immune cells to the ligands of these receptors activates intracellular signaling cascades that rapidly induce the expression of a variety of overlapping and unique genes involved in the inflammatory and immune responses. New insights into innate immunity are changing the way we think about pathogenesis and the treatment of infectious diseases, allergy, and autoimmunity. Pathogen recognition and innate immunity. S Akira S Uematsu O Takeuchi doi:10.1016/j.cell.2006.02.015 Cell, Vol. 124, No. 4. (24 February 2006), pp. 783-801. 2006-12-01T18:45:09-00:00 2006 Cell 0092-8674 124 4 783 801 tlrs-general http://www.citeulike.org/user/AlfonsoVicenteSuarez/article/1371322 <i>Nat Immunol, Vol. 2, No. 8. (August 2001), pp. 675-680.</i><br /><br />Recognition of pathogens is mediated by a set of germline-encoded receptors that are referred to as pattern-recognition receptors (PRRs). These receptors recognize conserved molecular patterns (pathogen-associated molecular patterns), which are shared by large groups of microorganisms. Toll-like receptors (TLRs) function as the PRRs in mammals and play an essential role in the recognition of microbial components. The TLRs may also recognize endogenous ligands induced during the inflammatory response. Similar cytoplasmic domains allow TLRs to use the same signaling molecules used by the interleukin 1 receptors (IL-1Rs): these include MyD88, IL-1R--associated protein kinase and tumor necrosis factor receptor--activated factor 6. However, evidence is accumulating that the signaling pathways associated with each TLR are not identical and may, therefore, result in different biological responses. Toll-like receptors: critical proteins linking innate and acquired immunity. S Akira K Takeda T Kaisho doi:10.1038/90609 Nat Immunol, Vol. 2, No. 8. (August 2001), pp. 675-680. 2007-06-07T20:31:40-00:00 2001 Nat Immunol 1529-2908 2 8 675 680 tlrs-general http://www.citeulike.org/user/AlfonsoVicenteSuarez/article/1371318 <i>Nat Immunol, Vol. 5, No. 10. (October 2004), pp. 987-995.</i> Toll-like receptor control of the adaptive immune responses Akiko Iwasaki Ruslan Medzhitov doi:10.1038/ni1112 Nat Immunol, Vol. 5, No. 10. (October 2004), pp. 987-995. 2007-06-07T20:23:55-00:00 2004 Nat Immunol 5 10 987 995 tlrs-general