Thu, 24 Jul 2008 23:25:29 BST CiteULike: AlfonsoVicenteSuarezs tolerance-models http://www.citeulike.org/user/AlfonsoVicenteSuarez/tag/tolerance-models CiteULike.org en-gb Copyright © 2004-2008 citeulike.org http://www.citeulike.org/user/AlfonsoVicenteSuarez/article/2911219 <i>J. Exp. Med., Vol. 195, No. 4. (11 February 2002), pp. 423-435.</i><br /><br />Using a tumor model of spontaneously arising insulinomas expressing a defined tumor-associated antigen, we investigated whether tumor growth promotes cross-presentation and tolerance of tumor-specific T cells. We found that an advanced tumor burden enhanced cross-presentation of tumor-associated antigens to high avidity tumor-specific T cells, inducing T cell proliferation and limited effector function in vivo. However, contrary to other models, tumor-specific T cells were not tolerized despite a high tumor burden. In fact, in tumor-bearing mice, persistence and responsiveness of adoptively transferred tumor-specific T cells were enhanced. Accordingly, a potent T cell-mediated antitumor response could be elicited by intravenous administration of tumor-derived peptide and agonistic anti-CD40 antibody or viral immunization and reimmunization. Thus, in this model, tumor growth promotes activation of high avidity tumor-specific T cells instead of tolerance. Therefore, the host remains responsive to T cell immunotherapy. 10.1084/jem.20010032 Tumor Growth Enhances Cross-Presentation Leading to Limited T Cell Activation without Tolerance Linh Nguyen Alisha Elford Kiichi Murakami Kristine Garza Stephen Schoenberger Bernhard Odermatt Daniel Speiser Pamela Ohashi doi:10.1084/jem.20010032 J. Exp. Med., Vol. 195, No. 4. (11 February 2002), pp. 423-435. 2008-06-20T17:43:30-00:00 2002 J. Exp. Med. 195 4 423 435 tolerance-models tumor-rejection http://www.citeulike.org/user/AlfonsoVicenteSuarez/article/1776829 <i></i> Intravenous injection of soluble antigen induces thymic and peripheral T-cell apoptosis -- Liblau et al. 93 (7): 3031 -- Proceedings of the National Academy of Sciences 2007-10-16T22:22:12-00:00 tolerance-models http://www.citeulike.org/user/AlfonsoVicenteSuarez/article/1776680 <i></i><br /><br />Encounters with antigen can stimulate T cells to become activated and proliferate, become nonresponsive to antigen, or to die. T cell death was shown to be a physiological response to interleukin-2-stimulated cell cycling and T cell receptor reengagement at high antigen doses. This feedback regulatory mechanism attenuates the immune response by deleting a portion of newly dividing, antigen-reactive T cells. This mechanism deleted autoreactive T cells and abrogated the clinical and pathological signs of autoimmune encephalomyelitis in mice after repetitive administration of myelin basic protein. T Cell Deletion in High Antigen Dose Therapy of Autoimmune Encephalomyelitis Jeffrey Critchfield Michael Racke Juan Zúñiga-Pflücker Barbara Cannella Cedric Raine Joan Goverman Michael Lenardo 2007-10-16T21:27:37-00:00 tolerance-models http://www.citeulike.org/user/AlfonsoVicenteSuarez/article/1776643 <i></i> Aqueous antigens induce in vivo tolerance selectively in IL-2- and IFN- gamma-producing (Th1) cells -- Burstein et al. 148 (12): 3687 -- The Journal of Immunology 2007-10-16T21:14:35-00:00 tolerance-models http://www.citeulike.org/user/AlfonsoVicenteSuarez/article/1776592 <i></i> Antigen-specific tolerance strategies for the prevention and treatment of autoimmune disease : Article : Nature Reviews Immunology 2007-10-16T20:58:41-00:00 tolerance-models