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Nøkkelord: activation [419 articles]

Nye artikler klassifisert med nøkkelordet activation.
  • notes Variability and robustness in T cell activation from regulated heterogeneity in protein levels.
    Science (New York, N.Y.), Vol. 321, No. 5892. (22 August 2008), pp. 1081-1084.
    by O Feinerman, J Veiga, JR Dorfman, RN Germain, G Altan-Bonnet
    posted to variety thesis t-cells signalling protein heterogeneity confounder activation by Zephyrus on 2008-09-27 18:46:23 as ** along with 1 person oelemento
  • Mediator and the mechanism of transcriptional activation.
    Trends Biochem Sci, Vol. 30, No. 5. (May 2005), pp. 235-239.
    by RD Kornberg
    posted to transcription review repressor mediator kornberg enhancer activator activation by xico on 2007-01-14 20:39:46 as ** along with 2 people and 1 group gloria hplatero WetBiology
  • Multiple residues in the second extracellular loop are critical for M3 muscarinic acetylcholine receptor activation.
    J Biol Chem, Vol. 282, No. 10. (9 March 2007), pp. 7385-7396.
    by M Scarselli, B Li, SK Kim, J Wess
    posted to activation amine binding ecl2 loops mutation by xdeupi on 2007-04-23 10:28:29 as **** along with 1 person and 1 group IrinaMoreira LabCompMed
  • Interacting Residues in an Activated State of a G Protein-coupled Receptor
    J. Biol. Chem., Vol. 281, No. 4. (27 January 2006), pp. 2263-2272.
    by Yong-Hun Lee, Fred Naider, Jeffrey M Becker
    posted to activation gpcr by xdeupi on 2006-01-23 17:17:33 as *** along with 1 group LabCompMed
  • Tertiary interactions between transmembrane segments 3 and 5 near the cytoplasmic side of rhodopsin.
    Biochemistry, Vol. 38, No. 37. (14 September 1999), pp. 12033-12040.
    by H Yu, DD Oprian
    posted to activation rhodopsin tm3 tm5 by xdeupi on 2006-03-08 15:15:54 as ** along with 1 group LabCompMed
  • Lessons from constitutively active mutants of G protein-coupled receptors.
    Trends Endocrinol Metab, Vol. 13, No. 8. (October 2002), pp. 336-343.
    by C Parnot, S Miserey-Lenkei, S Bardin, P Corvol, E Clauser
    posted to activation cam gpcr by xdeupi on 2005-11-01 20:08:05 as ** along with 1 group LabCompMed
  • Beta2 adrenergic receptor activation. Modulation of the proline kink in transmembrane 6 by a rotamer toggle switch.
    J Biol Chem, Vol. 277, No. 43. (25 October 2002), pp. 40989-40996.
    by L Shi, G Liapakis, R Xu, F Guarnieri, JA Ballesteros, JA Javitch
    posted to activation b2ar pro-kink switch tm6 toggle w648 by xdeupi on 2005-10-28 05:04:25 as read along with 1 person and 1 group IrinaMoreira LabCompMed
  • Dosage-dependent switch from G protein-coupled to G protein-independent signaling by a GPCR
    The EMBO Journal, Vol. aop, No. current. (14 December 2006)
    by Yutong Sun, Jianyun Huang, Yang Xiang, Murat Bastepe, Harald Juppner, Brian K Kobilka, Jillian J Zhang, Xin-Yun Huang
    posted to activation b2ar drug pharmacology switch by xdeupi on 2007-03-21 11:13:23 as ** along with 1 person and 1 group Guff32 LabCompMed
  • Activation of the beta 2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6.
    J Biol Chem, Vol. 276, No. 31. (3 August 2001), pp. 29171-29177.
    by JA Ballesteros, AD Jensen, G Liapakis, SG Rasmussen, L Shi, U Gether, JA Javitch
    posted to activation b2ar gpcr helix ionic lock pro-kink switch tm3 tm6 by xdeupi on 2005-11-01 00:58:31 as ** along with 1 person and 1 group IrinaMoreira LabCompMed
  • Critical role for the second extracellular loop in the binding of both orthosteric and allosteric G protein-coupled receptor ligands.
    J Biol Chem (25 June 2007)
    by Vimesh A A Avlani, Karen J J Gregory, Craig J J Morton, Michael W W Parker, Patrick M M Sexton, Arthur Christopoulos
    posted to activation binding ecl2 ligands loops structure by xdeupi on 2007-06-29 21:12:42 as ** along with 1 group LabCompMed
  • How a small change in retinal leads to G-protein activation: initial events suggested by molecular dynamics calculations.
    Proteins, Vol. 66, No. 3. (15 February 2007), pp. 559-574.
    by PS Crozier, MJ Stevens, TB Woolf
    posted to activation dynamics md modeling rhodopsin switch by xdeupi on 2007-02-26 09:15:15 as **** along with 1 group LabCompMed
  • Rhodopsin-interacting surface of the transducin gamma subunit.
    Biochemistry, Vol. 45, No. 31. (8 August 2006), pp. 9386-9392.
    by OG Kisselev, MA Downs
    posted to activation cterm gproteins icl3 rhodopsin by xdeupi on 2006-09-05 09:56:16 as ** along with 1 group LabCompMed
  • Common structural requirements for heptahelical domain function in class A and class C GPCRS.
    J Biol Chem (19 February 2007)
    by Virginie Binet, Béatrice Duthey, Jennifer Lecaillon, Claire Vol, Julie Quoyer, Gilles Labesse, Jean-Philippe P Pin, Laurent Prézeau
    posted to activation class_c gaba gpcr switch by xdeupi on 2007-02-26 09:21:25 as ** along with 1 group LabCompMed
  • Primary photoprocess in vision: minimal motion to reach the photo- and bathorhodopsin intermediates.
    J Phys Chem B, Vol. 109, No. 18. (12 May 2005), pp. 9104-9110.
    by F Blomgren, S Larsson
    posted to activation retinal rhodopsin theory by xdeupi on 2007-07-30 16:59:24 as ** along with 1 group LabCompMed
  • Activation of CCR5 by chemokines involves an aromatic cluster between transmembrane helices 2 and 3.
    J Biol Chem, Vol. 278, No. 3. (17 January 2003), pp. 1892-1903.
    by C Govaerts, A Bondue, JY Springael, M Olivella, X Deupi, E Le Poul, SJ Wodak, M Parmentier, L Pardo, C Blanpain
    posted to activation ccr5 helix tm2 tm3 by xdeupi on 2005-10-25 03:15:57 as read along with 1 person and 1 group tkershaw LabCompMed
  • NMR analysis of rhodopsin-transducin interactions.
    Vision Res, Vol. 46, No. 27. (December 2006), pp. 4482-4492.
    by KD Ridge, JP Marino, T Ngo, E Ramon, DM Brabazon, NG Abdulaev
    posted to activation gproteins nmr rhodopsin by xdeupi on 2007-02-20 09:54:49 as ** along with 1 group LabCompMed
  • Visual rhodopsin sees the light: Structure and mechanism of G protein signaling.
    J Biol Chem (8 February 2007)
    by Kevin D D Ridge, Krzysztof Palczewski
    posted to activation crystallography review rhodopsin by xdeupi on 2007-02-20 10:11:15 as ** along with 1 group LabCompMed
  • Crystallographic analysis of primary visual photochemistry.
    Angew Chem Int Ed Engl, Vol. 45, No. 26. (26 June 2006), pp. 4270-4273.
    by H Nakamichi, T Okada
    posted to activation crystallography rhodopsin structure by xdeupi on 2006-10-26 11:36:51 as ** along with 1 group LabCompMed
  • Role of group-conserved residues in the helical core of beta2-adrenergic receptor.
    Proc Natl Acad Sci U S A, Vol. 104, No. 17. (24 April 2007), pp. 7027-7032.
    by P Chelikani, V Hornak, M Eilers, PJ Reeves, SO Smith, UL Rajbhandary, HG Khorana
    posted to activation agonist b2ar ser switch tm4 by xdeupi on 2007-04-26 12:27:17 as ** along with 1 group LabCompMed
  • Requirement of rigid-body motion of transmembrane helices for light activation of rhodopsin.
    Science (New York, N.Y.), Vol. 274, No. 5288. (1 November 1996), pp. 768-770.
    by DL Farrens, C Altenbach, K Yang, WL Hubbell, HG Khorana
    posted to activation rhodopsin tm6 by xdeupi on 2008-08-08 19:00:11 as ** along with 1 group LabCompMed
  • A change in conformational dynamics underlies the activation of Eph receptor tyrosine kinases
    The EMBO Journal, Vol. aop, No. current. (14 September 2006)
    by Silke Wiesner, Leanne E Wybenga-Groot, Neil Warner, Hong Lin, Tony Pawson, Julie D Forman-Kay, Frank Sicheri
    posted to activation crystallography dynamics mutation nmr switch by xdeupi on 2006-11-17 20:55:01 as ** along with 1 group LabCompMed
  • Determination of network of residues that regulate allostery in protein families using sequence analysis.
    Protein Sci, Vol. 15, No. 2. (February 2006), pp. 258-268.
    by RI Dima, D Thirumalai
    posted to activation gpcr structure by xdeupi on 2006-01-30 09:31:44 as ***** along with 5 people and 1 group gbart nirfriedman choonpeng tale mingzhi LabCompMed
  • Activation of the CXCR3 chemokine receptor through anchoring of a small molecule chelator ligand between TM-III, -IV and -VI.
    Mol Pharmacol (14 December 2006)
    by Mette M M Rosenkilde, Michael B B Andersen, Rie Nygaard, Thomas M M Frimurer, Thue W W Schwartz
    posted to ligands ionic chemokine cation-pi agonist activation by xdeupi on 2007-01-11 16:06:35 as ** along with 1 group LabCompMed
  • Metal Ion Site Engineering Indicates a Global Toggle Switch Model for Seven-transmembrane Receptor Activation.
    J Biol Chem, Vol. 281, No. 25. (23 June 2006), pp. 17337-17346.
    by CE Elling, TM Frimurer, LO Gerlach, R Jorgensen, B Holst, TW Schwartz
    posted to activation b2ar modeling pro-kink structure switch toggle transmembrane by xdeupi on 2006-07-04 12:17:13 as read along with 1 person and 1 group IrinaMoreira LabCompMed
  • Molecular mechanism of 7TM receptor activation--a global toggle switch model.
    Annu Rev Pharmacol Toxicol, Vol. 46 (2006), pp. 481-519.
    by TW Schwartz, TM Frimurer, B Holst, MM Rosenkilde, CE Elling
    posted to activation gpcr helix modeling switch toggle by xdeupi on 2006-06-01 14:31:34 as read along with 1 person and 1 group superpyrin LabCompMed
  • Structures and spectral signatures of protonated water networks in bacteriorhodopsin.
    Proc Natl Acad Sci U S A, Vol. 104, No. 17. (24 April 2007), pp. 6980-6985.
    by G Mathias, D Marx
    posted to activation gpcr protonation retinal_binding_proteins rhodopsin theory water by xdeupi on 2007-06-11 10:25:44 as *** along with 1 person and 1 group saravan LabCompMed
  • Sequence analyses of G-protein-coupled receptors: similarities to rhodopsin.
    Biochemistry, Vol. 42, No. 10. (18 March 2003), pp. 2759-2767.
    by T Mirzadegan, G Benkö, S Filipek, K Palczewski
    posted to sequence rhodopsin lmc_101 gpcr activation by xdeupi on 2005-11-01 19:50:18 as read along with 1 group LabCompMed
  • Picosecond dynamics of G-protein coupled receptor activation in rhodopsin from time-resolved UV resonance Raman spectroscopy.
    Biochemistry, Vol. 42, No. 18. (13 May 2003), pp. 5169-5175.
    by JE Kim, D Pan, RA Mathies
    posted to activation dynamics fluorescence rhodopsin switch thyrotropin toggle w648 by xdeupi on 2006-06-02 12:33:11 as ** along with 1 group LabCompMed
  • G proteins in drug screening: from analysis of receptor-G protein specificity to manipulation of GPCR-mediated signalling pathways.
    Curr Pharm Des, Vol. 12, No. 14. (2006), pp. 1703-1715.
    by E Kostenis
    posted to activation cterm drug ecl2 gpcr gproteins pharmacology by xdeupi on 2006-09-05 09:59:05 as **** along with 1 group LabCompMed
  • A two-entropies analysis to identify functional positions in the transmembrane region of class A G protein-coupled receptors.
    Proteins, Vol. 63, No. 4. (1 June 2006), pp. 1018-1030.
    by K Ye, EW Lameijer, MW Beukers, AP Ijzerman
    posted to activation gpcr sequence transmembrane by xdeupi on 2006-07-24 10:21:33 as **** along with 2 people and 1 group cen4ik cat_worth LabCompMed
  • Evolutionary trace of G protein-coupled receptors reveals clusters of residues that determine global and class-specific functions.
    J Biol Chem, Vol. 279, No. 9. (27 February 2004), pp. 8126-8132.
    by S Madabushi, AK Gross, A Philippi, EC Meng, TG Wensel, O Lichtarge
    posted to activation binding gpcr sequence switch by xdeupi on 2005-11-01 20:03:29 as read along with 2 people and 1 group gbart sriram_s LabCompMed
  • Agonist-induced conformational changes in the G-protein-coupling domain of the beta 2 adrenergic receptor.
    Proc Natl Acad Sci U S A, Vol. 98, No. 11. (22 May 2001), pp. 5997-6002.
    by P Ghanouni, JJ Steenhuis, DL Farrens, BK Kobilka
    posted to activation agonist b2ar fluorescence by xdeupi on 2005-12-16 10:22:41 as ** along with 1 group LabCompMed
  • Photoisomerization mechanism of rhodopsin and 9-cis-rhodopsin revealed by x-ray crystallography.
    Biophys J, Vol. 92, No. 12. (15 June 2007)
    by H Nakamichi, V Buss, T Okada
    posted to activation retinal rhodopsin by xdeupi on 2007-07-30 16:57:47 as ** along with 1 group LabCompMed
  • Probing the beta2 adrenoceptor binding site with catechol reveals differences in binding and activation by agonists and partial agonists.
    J Biol Chem, Vol. 280, No. 23. (10 June 2005), pp. 22165-22171.
    by G Swaminath, X Deupi, TW Lee, W Zhu, FS Thian, TS Kobilka, B Kobilka
    posted to activation agonist b2ar switch toggle by xdeupi on 2005-10-25 01:25:28 as read along with 1 person and 3 groups marcius BioinfoCIPF LabCompMed SGU-CIPF
  • Principal pathway coupling agonist binding to channel gating in nicotinic receptors
    Nature, Vol. 438, No. 7065. (10 November 2005), pp. 243-247.
    by Won Y Lee, Steven M Sine
    posted to activation agonist binding channel ser by xdeupi on 2006-01-27 12:32:01 as ** along with 1 person and 3 groups barry structural_bioinformatics Bioinformatics LabCompMed
  • Mechanisms of Inter- and Intramolecular Communication in GPCRs and G Proteins
    J. Am. Chem. Soc. (12 March 2008)
    by F Raimondi, M Seeber, PG Debenedetti, F Fanelli
    posted to activation docking gpcr gproteins by xdeupi on 2008-05-03 17:09:50 as ** along with 1 person paulschlesinger
  • Proline-induced distortions of transmembrane helices.
    J Mol Biol, Vol. 323, No. 5. (8 November 2002), pp. 951-960.
    by FS Cordes, JN Bright, MS Sansom
    posted to activation helix membrane_proteins pro-kink structure theory transmembrane by xdeupi on 2008-05-27 11:58:27 as ** along with 1 person thaliana
  • beta-Arrestin-biased Agonism at the beta2-Adrenergic Receptor.
    J Biol Chem, Vol. 283, No. 9. (29 February 2008), pp. 5669-5676.
    by MT Drake, JD Violin, EJ Whalen, JW Wisler, SK Shenoy, RJ Lefkowitz
    posted to activation agonist arrestin b2ar biased_agonism drug gproteins imaging internalization ligands pharmacology by xdeupi on 2008-02-27 10:39:07 as *** along with 1 group LabCompMed
  • Can Conformational Change Be Described by Only a Few Normal Modes?
    Biophys. J., Vol. 90, No. 5. (1 March 2006), pp. 1583-1593.
    by Paula Petrone, Vijay S Pande
    posted to activation dynamics folding modeling by xdeupi on 2006-02-10 09:48:29 as ***** along with 10 people and 7 groups BragilMassoud barry dimka aqeel shuns yongzhao choonpeng joergkurtwegner daevans LamBras structural_bioinformatics Bioinformatics TSRI_MGL Molecular-Modelling Drug-Design Cheminformatics LabCompMed
  • Efficient coupling of transducin to monomeric rhodopsin in a phospholipid bilayer.
    J Biol Chem (22 November 2007)
    by Matthew R R Whorton, Beata Jastrzebska, Paul S-H S Park, Dimitrios Fotiadis, Andreas Engel, Krzysztof Palczewski, Roger K K Sunahara
    posted to activation dimer gproteins rhodopsin by xdeupi on 2008-03-12 17:12:36 as ** along with 1 person and 1 group gcaltabiano LabCompMed
  • New concepts in drug discovery: collateral efficacy and permissive antagonism.
    Nat Rev Drug Discov, Vol. 4, No. 11. (November 2005), pp. 919-927.
    by T Kenakin
    posted to activation agonist ccr5 gpcr ligands by xdeupi on 2005-11-04 21:57:24 as ** along with 1 group LabCompMed
  • Real-time analysis of agonist-induced activation of protease-activated receptor 1/Galphai1 protein complex measured by bioluminescence resonance energy transfer in living cells.
    Mol Pharmacol, Vol. 71, No. 5. (May 2007), pp. 1329-1340.
    by MA Ayoub, D Maurel, V Binet, M Fink, L Prézeau, H Ansanay, JP Pin
    posted to activation fret by xdeupi on 2007-06-02 19:29:56 as ** along with 1 group LabCompMed
  • Protein flexibility using constraints from molecular dynamics simulations.
    Phys Biol, Vol. 2, No. 4. (November 2005)
    by T Mamonova, B Hespenheide, R Straub, MF Thorpe, M Kurnikova
    posted to activation dynamics flexibility md by xdeupi on 2007-05-21 09:38:21 as ** along with 3 people and 1 group lna LamBras higueruelo LabCompMed
  • Predisposition of the dark state of rhodopsin to functional changes in structure
    Proteins: Structure, Function, and Bioinformatics, Vol. 65, No. 4. (2006), pp. 970-983.
    by Basak Isin, AJ Rader, Harpreet K Dhiman, Judith Klein-Seetharaman, Ivet Bahar
    posted to activation dynamics modeling rhodopsin by xdeupi on 2007-02-26 09:19:19 as **** along with 1 person and 1 group aqeel LabCompMed
  • Heterotrimeric G protein activation by G-protein-coupled receptors.
    Nat Rev Mol Cell Biol (28 November 2007)
    by William M M Oldham, Heidi E E Hamm
    posted to activation erc_grant gproteins rhodopsin by xdeupi on 2008-03-11 14:30:28 as ** along with 4 people and 2 groups dchughes Fritz mingzhi laurabailey neurolit LabCompMed
  • Coupling of retinal isomerization to the activation of rhodopsin
    PNAS, Vol. 101, No. 27. (6 July 2004), pp. 10048-10053.
    by Ashish B Patel, Evan Crocker, Markus Eilers, Amiram Hirshfeld, Mordechai Sheves, Steven O Smith
    posted to activation active-state nmr retinal rhodopsin by xdeupi on 2007-07-30 15:16:18 as ** along with 1 group LabCompMed
  • Mutations inducing divergent shifts of constitutive activity reveal different modes of binding among catecholamine analogues to the beta(2)-adrenergic receptor.
    Br J Pharmacol, Vol. 135, No. 7. (April 2002), pp. 1715-1722.
    by R Del Carmine, C Ambrosio, M Sbraccia, S Cotecchia, AP Ijzerman, T Costa
    posted to activation agonist b2ar by xdeupi on 2005-10-31 23:55:27 as **** along with 1 group LabCompMed
  • The specificity of binding of glycoprotein hormones to their receptors.
    Cellular and molecular life sciences : CMLS (26 April 2008)
    by G Caltabiano, M Campillo, A De Leener, G Smits, G Vassart, S Costagliola, L Pardo
    posted to activation hormone modeling thyrotropin by xdeupi on 2008-05-03 17:06:33 as ** along with 1 group LabCompMed
  • Structure-function of alpha1-adrenergic receptors.
    Biochem Pharmacol, Vol. 73, No. 8. (15 April 2007), pp. 1051-1062.
    by DM Perez
    posted to activation gpcr review by xdeupi on 2007-06-02 19:21:05 as ** along with 1 group LabCompMed
  • Dynamic models of G-protein coupled receptor dimers: indications of asymmetry in the rhodopsin dimer from molecular dynamics simulations in a POPC bilayer.
    J Comput Aided Mol Des (7 November 2006)
    by Marta Filizola, Simon X Wang, Harel Weinstein
    posted to activation dynamics gpcr lipids md membrane rhodopsin structure by xdeupi on 2006-11-14 16:42:29 as ** along with 1 group LabCompMed
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