Signaling to NF-kappaB

by: Matthew S Hayden, Sankar Ghosh

Genes Dev., Vol. 18, No. 18. (15 September 2004), pp. 2195-2224.

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Abstract

The transcription factor NF-kappaB has been the focus of intense investigation for nearly two decades. Over this period, considerable progress has been made in determining the function and regulation of NF-kappaB, although there are nuances in this important signaling pathway that still remain to be understood. The challenge now is to reconcile the regulatory complexity in this pathway with the complexity of responses in which NF-kappaB family members play important roles. In this review, we provide an overview of established NF-kappaB signaling pathways with focus on the current state of research into the mechanisms that regulate IKK activation and NF-kappaB transcriptional activity. 10.1101/gad.1228704

@article{citeulike:781960, abstract = {The transcription factor NF-{kappa}B has been the focus of intense investigation for nearly two decades. Over this period, considerable progress has been made in determining the function and regulation of NF-{kappa}B, although there are nuances in this important signaling pathway that still remain to be understood. The challenge now is to reconcile the regulatory complexity in this pathway with the complexity of responses in which NF-{kappa}B family members play important roles. In this review, we provide an overview of established NF-{kappa}B signaling pathways with focus on the current state of research into the mechanisms that regulate IKK activation and NF-{kappa}B transcriptional activity. 10.1101/gad.1228704}, author = {Hayden, Matthew S. and Ghosh, Sankar }, citeulike-article-id = {781960}, doi = {10.1101/gad.1228704}, journal = {Genes Dev.}, keywords = {nfkb, nf-kb, review, signal}, month = {September}, number = {18}, pages = {2195--2224}, posted-at = {2008-01-03 11:54:29}, priority = {2}, title = {Signaling to NF-{kappa}B}, url = {http://dx.doi.org/10.1101/gad.1228704}, volume = {18}, year = {2004} }

RIS record

TY - JOUR ID - citeulike:781960 L3 - citeulike-article-id:781960 TI - Signaling to NF-{kappa}B JF - Genes Dev. VL - 18 IS - 18 SP - 2195 EP - 2224 N2 - The transcription factor NF-{kappa}B has been the focus of intense investigation for nearly two decades. Over this period, considerable progress has been made in determining the function and regulation of NF-{kappa}B, although there are nuances in this important signaling pathway that still remain to be understood. The challenge now is to reconcile the regulatory complexity in this pathway with the complexity of responses in which NF-{kappa}B family members play important roles. In this review, we provide an overview of established NF-{kappa}B signaling pathways with focus on the current state of research into the mechanisms that regulate IKK activation and NF-{kappa}B transcriptional activity. 10.1101/gad.1228704 KW - nfkb KW - nf-kb KW - review KW - signal AU - Hayden, Matthew AU - Ghosh, Sankar PY - 2004/09/15/ UR - http://dx.doi.org/10.1101/gad.1228704 ER -

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