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Interleukin-12: A master regulator

by: Hema Bashyam
J. Exp. Med., Vol. 204, No. 5. (14 May 2007), 969.

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Early resistance to pathogens requires a swift response from NK cells. In 1989, Giorgio Trinchieri identified an NK growth factor and activator, later called interleukin-12 (IL-12). This discovery helped reveal the regulatory link between innate and adaptive immunity. 10.1084/jem.2045fta


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