Toll-like receptors in the pathogenesis of human disease.

by: DN Cook, DS Pisetsky, DA Schwartz

Nat Immunol, Vol. 5, No. 10. (October 2004), pp. 975-979.

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Abstract

Members of the Toll-like receptor (TLR) family are key regulators of both innate and adaptive immune responses. The function of TLRs in various human diseases has been investigated by comparison of the incidence of disease among people having different polymorphisms in genes that participate in TLR signaling. These studies have shown that TLR function affects several diseases, including sepsis, immunodeficiencies, atherosclerosis and asthma. As this body of data grows, it will provide new insights into disease pathogenesis as well as valuable information on the merits of various therapeutic options.

@article{citeulike:1371319, abstract = {Members of the Toll-like receptor (TLR) family are key regulators of both innate and adaptive immune responses. The function of TLRs in various human diseases has been investigated by comparison of the incidence of disease among people having different polymorphisms in genes that participate in TLR signaling. These studies have shown that TLR function affects several diseases, including sepsis, immunodeficiencies, atherosclerosis and asthma. As this body of data grows, it will provide new insights into disease pathogenesis as well as valuable information on the merits of various therapeutic options.}, address = {Department of Medicine, Duke University Medical Center, and the Durham Veterans Administration Medical Center, Durham, North Carolina 27710, USA. donald.cook@duke.edu <donald.cook@duke.edu>}, author = {Cook, D. N. and Pisetsky, D. S. and Schwartz, D. A. }, citeulike-article-id = {1371319}, doi = {10.1038/ni1116}, issn = {1529-2908}, journal = {Nat Immunol}, keywords = {tlrs-disease}, month = {October}, number = {10}, pages = {975--979}, posted-at = {2007-06-07 21:26:22}, priority = {2}, title = {Toll-like receptors in the pathogenesis of human disease.}, url = {http://dx.doi.org/10.1038/ni1116}, volume = {5}, year = {2004} }

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TY - JOUR ID - citeulike:1371319 L3 - citeulike-article-id:1371319 TI - Toll-like receptors in the pathogenesis of human disease. JF - Nat Immunol VL - 5 IS - 10 SP - 975 EP - 979 AD - Department of Medicine, Duke University Medical Center, and the Durham Veterans Administration Medical Center, Durham, North Carolina 27710, USA. donald.cook@duke.edu <donald.cook@duke.edu> SN - 1529-2908 N2 - Members of the Toll-like receptor (TLR) family are key regulators of both innate and adaptive immune responses. The function of TLRs in various human diseases has been investigated by comparison of the incidence of disease among people having different polymorphisms in genes that participate in TLR signaling. These studies have shown that TLR function affects several diseases, including sepsis, immunodeficiencies, atherosclerosis and asthma. As this body of data grows, it will provide new insights into disease pathogenesis as well as valuable information on the merits of various therapeutic options. KW - tlrs-disease AU - Cook, DN AU - Pisetsky, DS AU - Schwartz, DA PY - 2004/10// UR - http://dx.doi.org/10.1038/ni1116 ER -

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