The IL-12 Family of Heterodimeric Cytokines: New Players in the Regulation of T Cell Responses

by: Giorgio Trinchieri, Stefan Pflanz, Robert A Kastelein

Immunity, Vol. 19, No. 5. (November 2003), pp. 641-644.

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Abstract

Originally the only known heterodimeric cytokine, IL-12 is now part of a family of five cytokines and shares important functions in the regulation of both innate and adaptive immunity with two of them, IL-23 and IL-27. Although initially these three cytokines were considered to have largely overlapping immunological functions, more recent studies, including two articles in this issue of Immunity ( and ), indicate that they mediate complex and well-differentiated functions.

@article{citeulike:1387797, abstract = {Originally the only known heterodimeric cytokine, IL-12 is now part of a family of five cytokines and shares important functions in the regulation of both innate and adaptive immunity with two of them, IL-23 and IL-27. Although initially these three cytokines were considered to have largely overlapping immunological functions, more recent studies, including two articles in this issue of Immunity ( and ), indicate that they mediate complex and well-differentiated functions.}, author = {Trinchieri, Giorgio and Pflanz, Stefan and Kastelein, Robert A. }, citeulike-article-id = {1387797}, journal = {Immunity}, keywords = {il-12-general}, month = {November}, number = {5}, pages = {641--644}, posted-at = {2007-06-13 17:43:03}, priority = {2}, title = {The IL-12 Family of Heterodimeric Cytokines: New Players in the Regulation of T Cell Responses}, url = {http://www.sciencedirect.com/science/article/B6WSP-4B1RMYP-4/2/5050a99126d676b63f925048bda60247}, volume = {19}, year = {2003} }

RIS record

TY - JOUR ID - citeulike:1387797 TI - The IL-12 Family of Heterodimeric Cytokines: New Players in the Regulation of T Cell Responses JF - Immunity VL - 19 IS - 5 SP - 641 EP - 644 N2 - Originally the only known heterodimeric cytokine, IL-12 is now part of a family of five cytokines and shares important functions in the regulation of both innate and adaptive immunity with two of them, IL-23 and IL-27. Although initially these three cytokines were considered to have largely overlapping immunological functions, more recent studies, including two articles in this issue of Immunity ( and ), indicate that they mediate complex and well-differentiated functions. KW - il-12-general AU - Trinchieri, Giorgio AU - Pflanz, Stefan AU - Kastelein, Robert PY - 2003/11// UR - http://www.sciencedirect.com/science/article/B6WSP-4B1RMYP-4/2/5050a99126d676b63f925048bda60247 ER -

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