The biology of IL-12: coordinating innate and adaptive immune responses.

@article{citeulike:1387811, abstract = {Cytokines play critical roles in regulating all aspects of immune responses, including lymphoid development, homeostasis, differentiation, tolerance and memory. Interleukin (IL)-12 is especially important because its expression during infection regulates innate responses and determines the type and duration of adaptive immune response. IL-12 induces interferon-gamma (IFN-gamma) production by NK, T cells, dendritic cells (DC), and macrophages. IL-12 also promotes the differentiation of na\"{i}ve CD4+ T cells into T helper 1 (Th1) cells that produce IFN-gamma and aid in cell-mediated immunity. As IL-12 is induced by microbial products and regulates the development of adaptive immune cells, IL-12 plays a central role in coordinating innate and adaptive immunity. IL-12 and the recently identified cytokines, IL-23 and IL-27, define a family of related cytokines that induce IFN-gamma production and promote T cell expansion and proliferation.}, address = {Molecular Immunology and Inflammation Branch, NIAMS, National Institutes of Health, Bethesda, MD 20892, USA.}, author = {Watford, W. T. and Moriguchi, M. and Morinobu, A. and O'Shea, J. J. }, citeulike-article-id = {1387811}, issn = {1359-6101}, journal = {Cytokine Growth Factor Rev}, keywords = {il-12-general}, month = {October}, number = {5}, pages = {361--368}, posted-at = {2007-06-13 17:52:30}, priority = {2}, title = {The biology of IL-12: coordinating innate and adaptive immune responses.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/12948519}, volume = {14}, year = {2003} }

TY - JOUR ID - citeulike:1387811 L3 - citeulike-article-id:1387811 TI - The biology of IL-12: coordinating innate and adaptive immune responses. JF - Cytokine Growth Factor Rev VL - 14 IS - 5 SP - 361 EP - 368 AD - Molecular Immunology and Inflammation Branch, NIAMS, National Institutes of Health, Bethesda, MD 20892, USA. SN - 1359-6101 N2 - Cytokines play critical roles in regulating all aspects of immune responses, including lymphoid development, homeostasis, differentiation, tolerance and memory. Interleukin (IL)-12 is especially important because its expression during infection regulates innate responses and determines the type and duration of adaptive immune response. IL-12 induces interferon-gamma (IFN-gamma) production by NK, T cells, dendritic cells (DC), and macrophages. IL-12 also promotes the differentiation of naïve CD4+ T cells into T helper 1 (Th1) cells that produce IFN-gamma and aid in cell-mediated immunity. As IL-12 is induced by microbial products and regulates the development of adaptive immune cells, IL-12 plays a central role in coordinating innate and adaptive immunity. IL-12 and the recently identified cytokines, IL-23 and IL-27, define a family of related cytokines that induce IFN-gamma production and promote T cell expansion and proliferation. KW - il-12-general AU - Watford, WT AU - Moriguchi, M AU - Morinobu, A AU - O'Shea, JJ PY - 2003/10// UR - http://view.ncbi.nlm.nih.gov/pubmed/12948519 ER -