The primary mechanism of the IL-10-regulated antiinflammatory response is to selectively inhibit transcription

by: Peter J Murray

PNAS, Vol. 102, No. 24. (14 June 2005), pp. 8686-8691.

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Abstract

The antiinflammatory cytokine IL-10 inhibits the production of multiple, diverse inflammatory mediators from activated macrophages and dendritic cells, a process requiring STAT3 activation. However, the mechanisms involved in the broad inhibitory effects of IL-10 are controversial. I eliminated the contribution of the major confounding variable to understanding the antiinflammatory response, the 3' UTR region of inflammatory mediator genes, through knock-in mutation and analysis of the effects of IL-10 on transcription rate of inflammatory genes. IL-10 activates STAT3 to act indirectly by selectively inhibiting gene transcription independent of general effects on NF-kappaB or posttranscriptional mRNA processing through a process that reduces the overall transcriptional rate of specific genes. 10.1073/pnas.0500419102

@article{citeulike:1392182, abstract = {The antiinflammatory cytokine IL-10 inhibits the production of multiple, diverse inflammatory mediators from activated macrophages and dendritic cells, a process requiring STAT3 activation. However, the mechanisms involved in the broad inhibitory effects of IL-10 are controversial. I eliminated the contribution of the major confounding variable to understanding the antiinflammatory response, the 3' UTR region of inflammatory mediator genes, through knock-in mutation and analysis of the effects of IL-10 on transcription rate of inflammatory genes. IL-10 activates STAT3 to act indirectly by selectively inhibiting gene transcription independent of general effects on NF-{kappa}B or posttranscriptional mRNA processing through a process that reduces the overall transcriptional rate of specific genes. 10.1073/pnas.0500419102}, author = {Murray, Peter J. }, citeulike-article-id = {1392182}, doi = {10.1073/pnas.0500419102}, journal = {PNAS}, keywords = {il-10-general}, month = {June}, number = {24}, pages = {8686--8691}, posted-at = {2007-06-15 16:38:49}, priority = {2}, title = {The primary mechanism of the IL-10-regulated antiinflammatory response is to selectively inhibit transcription}, url = {http://dx.doi.org/10.1073/pnas.0500419102}, volume = {102}, year = {2005} }

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TY - JOUR ID - citeulike:1392182 L3 - citeulike-article-id:1392182 TI - The primary mechanism of the IL-10-regulated antiinflammatory response is to selectively inhibit transcription JF - PNAS VL - 102 IS - 24 SP - 8686 EP - 8691 N2 - The antiinflammatory cytokine IL-10 inhibits the production of multiple, diverse inflammatory mediators from activated macrophages and dendritic cells, a process requiring STAT3 activation. However, the mechanisms involved in the broad inhibitory effects of IL-10 are controversial. I eliminated the contribution of the major confounding variable to understanding the antiinflammatory response, the 3' UTR region of inflammatory mediator genes, through knock-in mutation and analysis of the effects of IL-10 on transcription rate of inflammatory genes. IL-10 activates STAT3 to act indirectly by selectively inhibiting gene transcription independent of general effects on NF-{kappa}B or posttranscriptional mRNA processing through a process that reduces the overall transcriptional rate of specific genes. 10.1073/pnas.0500419102 KW - il-10-general AU - Murray, Peter PY - 2005/06/14/ UR - http://dx.doi.org/10.1073/pnas.0500419102 ER -

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