Understanding and exploiting the endogenous interleukin-10/STAT3-mediated anti-inflammatory response

by: Peter J Murray

Current Opinion in Pharmacology, Vol. 6, No. 4. (August 2006), pp. 379-386.

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Abstract

Interleukin (IL)-10 performs an irreplaceable role in negatively regulating inflammation, primarily through a mechanism that selectively blocks the expression of pro-inflammatory genes encoding cytokines, chemokines, cell-surface molecules and other molecules involved in the propagation of inflammation. Not surprisingly, IL-10 has attracted interest as a tool to regulate inflammatory diseases. The clinical use of IL-10 as an anti-inflammatory agent has, however, not met expectations. Nevertheless, the signaling pathway used by the IL-10 receptor to generate the anti-inflammatory response is only beginning to be understood and could be a way to regulate inflammation by pharmacological agents.

@article{citeulike:1392189, abstract = {Interleukin (IL)-10 performs an irreplaceable role in negatively regulating inflammation, primarily through a mechanism that selectively blocks the expression of pro-inflammatory genes encoding cytokines, chemokines, cell-surface molecules and other molecules involved in the propagation of inflammation. Not surprisingly, IL-10 has attracted interest as a tool to regulate inflammatory diseases. The clinical use of IL-10 as an anti-inflammatory agent has, however, not met expectations. Nevertheless, the signaling pathway used by the IL-10 receptor to generate the anti-inflammatory response is only beginning to be understood and could be a way to regulate inflammation by pharmacological agents.}, author = {Murray, Peter J. }, booktitle = {Cancer/Immunomodulation}, citeulike-article-id = {1392189}, journal = {Current Opinion in Pharmacology}, keywords = {il-10-general}, month = {August}, number = {4}, pages = {379--386}, posted-at = {2007-06-15 16:42:20}, priority = {2}, title = {Understanding and exploiting the endogenous interleukin-10/STAT3-mediated anti-inflammatory response}, url = {http://www.sciencedirect.com/science/article/B6W7F-4K07FW1-1/2/56e8502faea01e28c38289deb192ed3f}, volume = {6}, year = {2006} }

RIS record

TY - JOUR ID - citeulike:1392189 L3 - citeulike-article-id:1392189 TI - Understanding and exploiting the endogenous interleukin-10/STAT3-mediated anti-inflammatory response T2 - Cancer/Immunomodulation JF - Current Opinion in Pharmacology VL - 6 IS - 4 SP - 379 EP - 386 N2 - Interleukin (IL)-10 performs an irreplaceable role in negatively regulating inflammation, primarily through a mechanism that selectively blocks the expression of pro-inflammatory genes encoding cytokines, chemokines, cell-surface molecules and other molecules involved in the propagation of inflammation. Not surprisingly, IL-10 has attracted interest as a tool to regulate inflammatory diseases. The clinical use of IL-10 as an anti-inflammatory agent has, however, not met expectations. Nevertheless, the signaling pathway used by the IL-10 receptor to generate the anti-inflammatory response is only beginning to be understood and could be a way to regulate inflammation by pharmacological agents. KW - il-10-general AU - Murray, Peter PY - 2006/08// UR - http://www.sciencedirect.com/science/article/B6W7F-4K07FW1-1/2/56e8502faea01e28c38289deb192ed3f ER -

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