Interleukin-10 production by effector T cells: Th1 cells show self control

by: Giorgio Trinchieri

J. Exp. Med., Vol. 204, No. 2. (19 February 2007), pp. 239-243.

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Abstract

Interleukin (IL)-10 is a cytokine that modulates both innate and adaptive immunity, primarily by exerting antiinflammatory effects. IL-10 was originally thought to be produced only by T helper (Th)2 cells, but is now known to be made by a variety of cell types. During many infections, CD4+ T cells produce both interferon (IFN)-gamma, the signature Th1 cytokine, and IL-10. New data now show that the IL-10 produced by effector Th1 cells helps limit the collateral damage caused by exaggerated inflammation. But this control may also limit the effectiveness of the immune response, resulting in a failure to fully eliminate pathogens. 10.1084/jem.20070104

@article{citeulike:1402623, abstract = {Interleukin (IL)-10 is a cytokine that modulates both innate and adaptive immunity, primarily by exerting antiinflammatory effects. IL-10 was originally thought to be produced only by T helper (Th)2 cells, but is now known to be made by a variety of cell types. During many infections, CD4+ T cells produce both interferon (IFN)-{gamma}, the signature Th1 cytokine, and IL-10. New data now show that the IL-10 produced by effector Th1 cells helps limit the collateral damage caused by exaggerated inflammation. But this control may also limit the effectiveness of the immune response, resulting in a failure to fully eliminate pathogens. 10.1084/jem.20070104}, author = {Trinchieri, Giorgio }, citeulike-article-id = {1402623}, doi = {10.1084/jem.20070104}, journal = {J. Exp. Med.}, keywords = {il-10-tcells}, month = {February}, number = {2}, pages = {239--243}, posted-at = {2007-06-21 16:07:06}, priority = {2}, title = {Interleukin-10 production by effector T cells: Th1 cells show self control}, url = {http://dx.doi.org/10.1084/jem.20070104}, volume = {204}, year = {2007} }

RIS record

TY - JOUR ID - citeulike:1402623 TI - Interleukin-10 production by effector T cells: Th1 cells show self control JF - J. Exp. Med. VL - 204 IS - 2 SP - 239 EP - 243 N2 - Interleukin (IL)-10 is a cytokine that modulates both innate and adaptive immunity, primarily by exerting antiinflammatory effects. IL-10 was originally thought to be produced only by T helper (Th)2 cells, but is now known to be made by a variety of cell types. During many infections, CD4+ T cells produce both interferon (IFN)-{gamma}, the signature Th1 cytokine, and IL-10. New data now show that the IL-10 produced by effector Th1 cells helps limit the collateral damage caused by exaggerated inflammation. But this control may also limit the effectiveness of the immune response, resulting in a failure to fully eliminate pathogens. 10.1084/jem.20070104 KW - il-10-tcells AU - Trinchieri, Giorgio PY - 2007/02/19/ UR - http://dx.doi.org/10.1084/jem.20070104 ER -

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