Retinoic acid early inducible genes define a ligand family for the activating NKG2D receptor in mice.

by: A Cerwenka, AB Bakker, T McClanahan, J Wagner, J Wu, JH Phillips, LL Lanier

Immunity, Vol. 12, No. 6. (June 2000), pp. 721-727.

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Abstract

Here we describe a family of GPI-anchored cell surface proteins that function as ligands for the mouse activating NKG2D receptor. These molecules are encoded by the retinoic acid early inducible (RAE-1) and H60 minor histocompatibility antigen genes on mouse chromosome 10 and show weak homology with MHC class I. Expression of the NKG2D ligands is low or absent on normal, adult tissues; however, they are constitutively expressed on some tumors and upregulated by retinoic acid. Ectopic expression of RAE-1 and H60 confers target susceptibility to NK cell attack. These studies identify a family of ligands for the activating NKG2D receptor on NK and T cells, which may play an important role in innate and adaptive immunity.

@article{citeulike:1452955, abstract = {Here we describe a family of GPI-anchored cell surface proteins that function as ligands for the mouse activating NKG2D receptor. These molecules are encoded by the retinoic acid early inducible (RAE-1) and H60 minor histocompatibility antigen genes on mouse chromosome 10 and show weak homology with MHC class I. Expression of the NKG2D ligands is low or absent on normal, adult tissues; however, they are constitutively expressed on some tumors and upregulated by retinoic acid. Ectopic expression of RAE-1 and H60 confers target susceptibility to NK cell attack. These studies identify a family of ligands for the activating NKG2D receptor on NK and T cells, which may play an important role in innate and adaptive immunity.}, address = {Department of Microbiology and Immunology and The Cancer Research Institute, University of California, San Francisco 94143, USA.}, author = {Cerwenka, A. and Bakker, A. B. and McClanahan, T. and Wagner, J. and Wu, J. and Phillips, J. H. and Lanier, L. L. }, citeulike-article-id = {1452955}, issn = {1074-7613}, journal = {Immunity}, keywords = {ra, rae-1}, month = {June}, number = {6}, pages = {721--727}, posted-at = {2008-05-10 00:26:31}, priority = {2}, title = {Retinoic acid early inducible genes define a ligand family for the activating NKG2D receptor in mice.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/10894171}, volume = {12}, year = {2000} }

RIS record

TY - JOUR ID - citeulike:1452955 TI - Retinoic acid early inducible genes define a ligand family for the activating NKG2D receptor in mice. JF - Immunity VL - 12 IS - 6 SP - 721 EP - 727 AD - Department of Microbiology and Immunology and The Cancer Research Institute, University of California, San Francisco 94143, USA. SN - 1074-7613 N2 - Here we describe a family of GPI-anchored cell surface proteins that function as ligands for the mouse activating NKG2D receptor. These molecules are encoded by the retinoic acid early inducible (RAE-1) and H60 minor histocompatibility antigen genes on mouse chromosome 10 and show weak homology with MHC class I. Expression of the NKG2D ligands is low or absent on normal, adult tissues; however, they are constitutively expressed on some tumors and upregulated by retinoic acid. Ectopic expression of RAE-1 and H60 confers target susceptibility to NK cell attack. These studies identify a family of ligands for the activating NKG2D receptor on NK and T cells, which may play an important role in innate and adaptive immunity. KW - ra KW - rae-1 AU - Cerwenka, A AU - Bakker, AB AU - McClanahan, T AU - Wagner, J AU - Wu, J AU - Phillips, JH AU - Lanier, LL PY - 2000/06// UR - http://view.ncbi.nlm.nih.gov/pubmed/10894171 ER -

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