Generation, migration and function of circulating dendritic cells

by: Roberto Bonasio, Ulrich H von Andrian

Current Opinion in Immunology, Vol. 18, No. 4. (August 2006), pp. 503-511.

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Abstract

Tissue-resident dendritic cells (DCs) that migrate from peripheral sites to lymphoid organs are essential in the initiation of adaptive immune responses and for the maintenance of peripheral tolerance, and have been extensively studied. By contrast, blood-borne DCs represent a heterogeneous population, the origin, destination and function of which are still unclear. Recent studies have shown that circulating DCs capture blood-borne antigen and transport it into the extra-vascular space of lymphoid tissues for processing and presentation. Other findings suggest that a fraction of tissue-resident DCs might enter the blood after having acquired antigen in the periphery. Together, these studies imply that circulating DCs might modulate immune responses by translocating antigenic material from its point of origin to remote target tissues.

@article{citeulike:1751306, abstract = {Tissue-resident dendritic cells (DCs) that migrate from peripheral sites to lymphoid organs are essential in the initiation of adaptive immune responses and for the maintenance of peripheral tolerance, and have been extensively studied. By contrast, blood-borne DCs represent a heterogeneous population, the origin, destination and function of which are still unclear. Recent studies have shown that circulating DCs capture blood-borne antigen and transport it into the extra-vascular space of lymphoid tissues for processing and presentation. Other findings suggest that a fraction of tissue-resident DCs might enter the blood after having acquired antigen in the periphery. Together, these studies imply that circulating DCs might modulate immune responses by translocating antigenic material from its point of origin to remote target tissues.}, author = {Bonasio, Roberto and von Andrian, Ulrich H. }, booktitle = {Host-pathogen interactions / Immunological techniques}, citeulike-article-id = {1751306}, doi = {10.1016/j.coi.2006.05.011}, journal = {Current Opinion in Immunology}, keywords = {migration-dcs}, month = {August}, number = {4}, pages = {503--511}, posted-at = {2007-10-10 17:33:09}, priority = {2}, title = {Generation, migration and function of circulating dendritic cells}, url = {http://dx.doi.org/10.1016/j.coi.2006.05.011}, volume = {18}, year = {2006} }

RIS record

TY - JOUR ID - citeulike:1751306 L3 - citeulike-article-id:1751306 TI - Generation, migration and function of circulating dendritic cells T2 - Host-pathogen interactions / Immunological techniques JF - Current Opinion in Immunology VL - 18 IS - 4 SP - 503 EP - 511 N2 - Tissue-resident dendritic cells (DCs) that migrate from peripheral sites to lymphoid organs are essential in the initiation of adaptive immune responses and for the maintenance of peripheral tolerance, and have been extensively studied. By contrast, blood-borne DCs represent a heterogeneous population, the origin, destination and function of which are still unclear. Recent studies have shown that circulating DCs capture blood-borne antigen and transport it into the extra-vascular space of lymphoid tissues for processing and presentation. Other findings suggest that a fraction of tissue-resident DCs might enter the blood after having acquired antigen in the periphery. Together, these studies imply that circulating DCs might modulate immune responses by translocating antigenic material from its point of origin to remote target tissues. KW - migration-dcs AU - Bonasio, Roberto AU - von Andrian, Ulrich PY - 2006/08// UR - http://dx.doi.org/10.1016/j.coi.2006.05.011 ER -

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