T Cell Deletion in High Antigen Dose Therapy of Autoimmune Encephalomyelitis

@article{citeulike:1776680, abstract = {Encounters with antigen can stimulate T cells to become activated and proliferate, become nonresponsive to antigen, or to die. T cell death was shown to be a physiological response to interleukin-2-stimulated cell cycling and T cell receptor reengagement at high antigen doses. This feedback regulatory mechanism attenuates the immune response by deleting a portion of newly dividing, antigen-reactive T cells. This mechanism deleted autoreactive T cells and abrogated the clinical and pathological signs of autoimmune encephalomyelitis in mice after repetitive administration of myelin basic protein.}, author = {Critchfield, Jeffrey M. and Racke, Michael K. and Z\'{u}\~{n}iga-Pfl\"{u}cker, Juan C. and Cannella, Barbara and Raine, Cedric S. and Goverman, Joan and Lenardo, Michael J. }, citeulike-article-id = {1776680}, keywords = {tolerance-models}, posted-at = {2007-10-16 22:27:50}, priority = {2}, title = {T Cell Deletion in High Antigen Dose Therapy of Autoimmune Encephalomyelitis}, url = {http://www.jstor.org/stable/2883427} }

TY - JOUR ID - citeulike:1776680 L3 - citeulike-article-id:1776680 TI - T Cell Deletion in High Antigen Dose Therapy of Autoimmune Encephalomyelitis N2 - Encounters with antigen can stimulate T cells to become activated and proliferate, become nonresponsive to antigen, or to die. T cell death was shown to be a physiological response to interleukin-2-stimulated cell cycling and T cell receptor reengagement at high antigen doses. This feedback regulatory mechanism attenuates the immune response by deleting a portion of newly dividing, antigen-reactive T cells. This mechanism deleted autoreactive T cells and abrogated the clinical and pathological signs of autoimmune encephalomyelitis in mice after repetitive administration of myelin basic protein. KW - tolerance-models AU - Critchfield, Jeffrey AU - Racke, Michael AU - Zúñiga-Pflücker, Juan AU - Cannella, Barbara AU - Raine, Cedric AU - Goverman, Joan AU - Lenardo, Michael UR - http://www.jstor.org/stable/2883427 ER -