Anatomical basis of tolerance and immunity to intestinal antigens.

by: AM Mowat

Nat Rev Immunol, Vol. 3, No. 4. (April 2003), pp. 331-341.

View FullText article

DOI, Pubmed, Hubmed

Reviews [Write a review of this article]

There are no reviews of this article

Find related articles from these CiteULike users

AlfonsoVicenteSuarez

Find related articles with these CiteULike tags

anatomy-immune

Abstract

The intestinal immune system has to discriminate between harmful and beneficial antigens. Although strong protective immunity is essential to prevent invasion by pathogens, equivalent responses against dietary proteins or commensal bacteria can lead to chronic disease. These responses are normally prevented by a complex interplay of regulatory mechanisms. This article reviews the unique aspects of the local microenvironment of the intestinal immune system and discuss how these promote the development of regulatory responses that ensure the maintenance of homeostasis in the gut.

@article{citeulike:2319930, abstract = {The intestinal immune system has to discriminate between harmful and beneficial antigens. Although strong protective immunity is essential to prevent invasion by pathogens, equivalent responses against dietary proteins or commensal bacteria can lead to chronic disease. These responses are normally prevented by a complex interplay of regulatory mechanisms. This article reviews the unique aspects of the local microenvironment of the intestinal immune system and discuss how these promote the development of regulatory responses that ensure the maintenance of homeostasis in the gut.}, address = {Department of Immunology and Bacteriology, Western Infirmary, Glasgow G11 6NT, UK. a.m.mowat@clinmed.gla.ac.uk}, author = {Mowat, A. M. }, citeulike-article-id = {2319930}, doi = {10.1038/nri1057}, issn = {1474-1733}, journal = {Nat Rev Immunol}, keywords = {anatomy-immune}, month = {April}, number = {4}, pages = {331--341}, posted-at = {2008-02-01 16:13:22}, priority = {2}, title = {Anatomical basis of tolerance and immunity to intestinal antigens.}, url = {http://dx.doi.org/10.1038/nri1057}, volume = {3}, year = {2003} }

RIS record

TY - JOUR ID - citeulike:2319930 TI - Anatomical basis of tolerance and immunity to intestinal antigens. JF - Nat Rev Immunol VL - 3 IS - 4 SP - 331 EP - 341 AD - Department of Immunology and Bacteriology, Western Infirmary, Glasgow G11 6NT, UK. a.m.mowat@clinmed.gla.ac.uk SN - 1474-1733 N2 - The intestinal immune system has to discriminate between harmful and beneficial antigens. Although strong protective immunity is essential to prevent invasion by pathogens, equivalent responses against dietary proteins or commensal bacteria can lead to chronic disease. These responses are normally prevented by a complex interplay of regulatory mechanisms. This article reviews the unique aspects of the local microenvironment of the intestinal immune system and discuss how these promote the development of regulatory responses that ensure the maintenance of homeostasis in the gut. KW - anatomy-immune AU - Mowat, AM PY - 2003/04// UR - http://dx.doi.org/10.1038/nri1057 ER -

RIS BibTeX