DNA-based vaccines activate innate and adaptive antitumor immunity by engaging the NKG2D receptor

@article{citeulike:2782017, abstract = {The interaction of NKG2D, a stimulatory receptor expressed on natural killer (NK) cells and activated CD8+ T cells, and its ligands mediates stimulatory and costimulatory signals to these cells. Here, we demonstrate that DNA-based vaccines, encoding syngeneic or allogeneic NKG2D ligands together with tumor antigens such as survivin or carcinoembryonic antigen, markedly activate both innate and adaptive antitumor immunity. Such vaccines result in highly effective, NK- and CD8+ T cell-mediated protection against either breast or colon carcinoma cells in prophylactic and therapeutic settings. Notably, this protection was irrespective of the NKG2D ligand expression level of the tumor cells. Hence, this strategy has the potential to lead to widely applicable and possibly clinically useful DNA-based cancer vaccines. 10.1073/pnas.0502208102}, author = {Zhou, He and Luo, Yunping and Lo, Jeng-Fan and Kaplan, Charles D. and Mizutani, Masato and Mizutani, Noriko and Lee, Jiing-Dwan and Primus, James F. and Becker, Jurgen C. and Xiang, Rong and Reisfeld, Ralph A. }, citeulike-article-id = {2782017}, doi = {10.1073/pnas.0502208102}, journal = {Proceedings of the National Academy of Sciences}, keywords = {ra, rae-1}, month = {August}, number = {31}, pages = {10846--10851}, posted-at = {2008-05-10 00:50:09}, priority = {2}, title = {DNA-based vaccines activate innate and adaptive antitumor immunity by engaging the NKG2D receptor}, url = {http://dx.doi.org/10.1073/pnas.0502208102}, volume = {102}, year = {2005} }

TY - JOUR ID - citeulike:2782017 TI - DNA-based vaccines activate innate and adaptive antitumor immunity by engaging the NKG2D receptor JF - Proceedings of the National Academy of Sciences VL - 102 IS - 31 SP - 10846 EP - 10851 N2 - The interaction of NKG2D, a stimulatory receptor expressed on natural killer (NK) cells and activated CD8+ T cells, and its ligands mediates stimulatory and costimulatory signals to these cells. Here, we demonstrate that DNA-based vaccines, encoding syngeneic or allogeneic NKG2D ligands together with tumor antigens such as survivin or carcinoembryonic antigen, markedly activate both innate and adaptive antitumor immunity. Such vaccines result in highly effective, NK- and CD8+ T cell-mediated protection against either breast or colon carcinoma cells in prophylactic and therapeutic settings. Notably, this protection was irrespective of the NKG2D ligand expression level of the tumor cells. Hence, this strategy has the potential to lead to widely applicable and possibly clinically useful DNA-based cancer vaccines. 10.1073/pnas.0502208102 KW - ra KW - rae-1 AU - Zhou, He AU - Luo, Yunping AU - Lo, Jeng-Fan AU - Kaplan, Charles AU - Mizutani, Masato AU - Mizutani, Noriko AU - Lee, Jiing-Dwan AU - Primus, James AU - Becker, Jurgen AU - Xiang, Rong AU - Reisfeld, Ralph PY - 2005/08/02/ UR - http://dx.doi.org/10.1073/pnas.0502208102 ER -