Regulation of inflammatory responses by IL-17F

@article{citeulike:2911229, abstract = {Although interleukin (IL) 17 has been extensively characterized, the function of IL-17F, which has an expression pattern regulated similarly to IL-17, is poorly understood. We show that like IL-17, IL-17F regulates proinflammatory gene expression in vitro, and this requires IL-17 receptor A, tumor necrosis factor receptor-associated factor 6, and Act1. In vivo, overexpression of IL-17F in lung epithelium led to infiltration of lymphocytes and macrophages and mucus hyperplasia, similar to observations made in IL-17 transgenic mice. To further understand the function of IL-17F, we generated and analyzed mice deficient in IL-17F or IL-17. IL-17, but not IL-17F, was required for the initiation of experimental autoimmune encephalomyelitis. Mice deficient in IL-17F, but not IL-17, had defective airway neutrophilia in response to allergen challenge. Moreover, in an asthma model, although IL-17 deficiency reduced T helper type 2 responses, IL-17F-deficient mice displayed enhanced type 2 cytokine production and eosinophil function. In addition, IL-17F deficiency resulted in reduced colitis caused by dextran sulfate sodium, whereas IL-17 knockout mice developed more severe disease. Our results thus demonstrate that IL-17F is an important regulator of inflammatory responses that seems to function differently than IL-17 in immune responses and diseases. 10.1084/jem.20071978}, author = {Yang, Xuexian O. and Chang, Seon H. and Park, Heon and Nurieva, Roza and Shah, Bhavin and Acero, Luis and Wang, Yi-Hong and Schluns, Kimberly S. and Broaddus, Russell R. and Zhu, Zhou and Dong, Chen }, citeulike-article-id = {2911229}, doi = {http://dx.doi.org/10.1084/jem.20071978}, journal = {J. Exp. Med.}, keywords = {il-17}, month = {May}, number = {5}, pages = {1063--1075}, posted-at = {2008-06-20 18:51:49}, priority = {2}, title = {Regulation of inflammatory responses by IL-17F}, url = {http://dx.doi.org/10.1084/jem.20071978}, volume = {205}, year = {2008} }

TY - JOUR ID - citeulike:2911229 L3 - citeulike-article-id:2911229 TI - Regulation of inflammatory responses by IL-17F JF - J. Exp. Med. VL - 205 IS - 5 SP - 1063 EP - 1075 N2 - Although interleukin (IL) 17 has been extensively characterized, the function of IL-17F, which has an expression pattern regulated similarly to IL-17, is poorly understood. We show that like IL-17, IL-17F regulates proinflammatory gene expression in vitro, and this requires IL-17 receptor A, tumor necrosis factor receptor-associated factor 6, and Act1. In vivo, overexpression of IL-17F in lung epithelium led to infiltration of lymphocytes and macrophages and mucus hyperplasia, similar to observations made in IL-17 transgenic mice. To further understand the function of IL-17F, we generated and analyzed mice deficient in IL-17F or IL-17. IL-17, but not IL-17F, was required for the initiation of experimental autoimmune encephalomyelitis. Mice deficient in IL-17F, but not IL-17, had defective airway neutrophilia in response to allergen challenge. Moreover, in an asthma model, although IL-17 deficiency reduced T helper type 2 responses, IL-17F-deficient mice displayed enhanced type 2 cytokine production and eosinophil function. In addition, IL-17F deficiency resulted in reduced colitis caused by dextran sulfate sodium, whereas IL-17 knockout mice developed more severe disease. Our results thus demonstrate that IL-17F is an important regulator of inflammatory responses that seems to function differently than IL-17 in immune responses and diseases. 10.1084/jem.20071978 KW - il-17 AU - Yang, Xuexian AU - Chang, Seon AU - Park, Heon AU - Nurieva, Roza AU - Shah, Bhavin AU - Acero, Luis AU - Wang, Yi-Hong AU - Schluns, Kimberly AU - Broaddus, Russell AU - Zhu, Zhou AU - Dong, Chen PY - 2008/05/12/ UR - http://dx.doi.org/10.1084/jem.20071978 ER -