Two Functional Subsets of FOXP3+ Regulatory T Cells in Human Thymus and Periphery

@article{citeulike:2953830, abstract = {Summary Previous studies suggest that thymus produces a homogenous population of natural regulatory T (Treg) cells that express a transcriptional factor FOXP3 and control autoimmunity through a cell-contact-dependent mechanism. We found two subsets of FOXP3+ natural Treg cells defined by the expression of the costimulatory molecule ICOS in the human thymus and periphery. Whereas the ICOS+FOXP3+ Treg cells used interleukin-10 to suppress dendritic cell function and transforming growth factor (TGF)-[beta] to suppress T cell function, the ICOS-FOXP3+ Treg cells used TGF-[beta] only. The survival and proliferation of the two subsets of Treg cells were differentially regulated by signaling through ICOS or CD28, respectively. We suggest that the selection of natural Treg cells in thymus is coupled with Treg cell differentiation into two subsets imprinted with different cytokine expression potentials and use both cell-contact-dependent and independent mechanisms for immunosuppression in periphery.}, author = {Ito, Tomoki and Hanabuchi, Shino and Wang, Yi-Hong and Park, Woong R. and Arima, Kazuhiko and Bover, Laura and Qin, Xiao-Feng F. and Gilliet, Michel and Liu, Yong-Jun }, citeulike-article-id = {2953830}, doi = {http://dx.doi.org/10.1016/j.immuni.2008.03.018}, journal = {Immunity}, keywords = {t-regs}, month = {June}, number = {6}, pages = {870--880}, posted-at = {2008-07-02 22:15:57}, priority = {2}, title = {Two Functional Subsets of FOXP3+ Regulatory T Cells in Human Thymus and Periphery}, url = {http://dx.doi.org/10.1016/j.immuni.2008.03.018}, volume = {28}, year = {2008} }

TY - JOUR ID - citeulike:2953830 L3 - citeulike-article-id:2953830 TI - Two Functional Subsets of FOXP3+ Regulatory T Cells in Human Thymus and Periphery JF - Immunity VL - 28 IS - 6 SP - 870 EP - 880 N2 - Summary Previous studies suggest that thymus produces a homogenous population of natural regulatory T (Treg) cells that express a transcriptional factor FOXP3 and control autoimmunity through a cell-contact-dependent mechanism. We found two subsets of FOXP3+ natural Treg cells defined by the expression of the costimulatory molecule ICOS in the human thymus and periphery. Whereas the ICOS+FOXP3+ Treg cells used interleukin-10 to suppress dendritic cell function and transforming growth factor (TGF)-[beta] to suppress T cell function, the ICOS-FOXP3+ Treg cells used TGF-[beta] only. The survival and proliferation of the two subsets of Treg cells were differentially regulated by signaling through ICOS or CD28, respectively. We suggest that the selection of natural Treg cells in thymus is coupled with Treg cell differentiation into two subsets imprinted with different cytokine expression potentials and use both cell-contact-dependent and independent mechanisms for immunosuppression in periphery. KW - t-regs AU - Ito, Tomoki AU - Hanabuchi, Shino AU - Wang, Yi-Hong AU - Park, Woong AU - Arima, Kazuhiko AU - Bover, Laura AU - Qin, Xiao-Feng AU - Gilliet, Michel AU - Liu, Yong-Jun PY - 2008/06/13/ UR - http://dx.doi.org/10.1016/j.immuni.2008.03.018 ER -