Inferences, questions and possibilities in Toll-like receptor signalling.

@article{citeulike:477346, abstract = {The Toll-like receptors (TLRs) are the key proteins that allow mammals--whether immunologically naive or experienced--to detect microbes. They lie at the core of our inherited resistance to disease, initiating most of the phenomena that occur in the course of infection. Quasi-infectious stimuli that have been used for decades to study inflammatory mechanisms can activate the TLR family of proteins. And it now seems that many inflammatory processes, both sterile and infectious, may depend on TLR signalling. We are in a good position to apply our understanding of TLR signalling to a range of challenges in immunology and medicine.}, address = {Department of Immunology, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, California 92037, USA. bruce@scripps.edu}, author = {Beutler, B. }, citeulike-article-id = {477346}, doi = {10.1038/nature02761}, issn = {1476-4687}, journal = {Nature}, keywords = {tlr-signaling}, month = {July}, number = {6996}, pages = {257--263}, posted-at = {2007-06-07 21:29:01}, priority = {2}, title = {Inferences, questions and possibilities in Toll-like receptor signalling.}, url = {http://dx.doi.org/10.1038/nature02761}, volume = {430}, year = {2004} }

TY - JOUR ID - citeulike:477346 L3 - citeulike-article-id:477346 TI - Inferences, questions and possibilities in Toll-like receptor signalling. JF - Nature VL - 430 IS - 6996 SP - 257 EP - 263 AD - Department of Immunology, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, California 92037, USA. bruce@scripps.edu SN - 1476-4687 N2 - The Toll-like receptors (TLRs) are the key proteins that allow mammals--whether immunologically naive or experienced--to detect microbes. They lie at the core of our inherited resistance to disease, initiating most of the phenomena that occur in the course of infection. Quasi-infectious stimuli that have been used for decades to study inflammatory mechanisms can activate the TLR family of proteins. And it now seems that many inflammatory processes, both sterile and infectious, may depend on TLR signalling. We are in a good position to apply our understanding of TLR signalling to a range of challenges in immunology and medicine. KW - tlr-signaling AU - Beutler, B PY - 2004/07/08/ UR - http://dx.doi.org/10.1038/nature02761 ER -