Pathogen recognition and innate immunity.

by: S Akira, S Uematsu, O Takeuchi

Cell, Vol. 124, No. 4. (24 February 2006), pp. 783-801.

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Abstract

Microorganisms that invade a vertebrate host are initially recognized by the innate immune system through germline-encoded pattern-recognition receptors (PRRs). Several classes of PRRs, including Toll-like receptors and cytoplasmic receptors, recognize distinct microbial components and directly activate immune cells. Exposure of immune cells to the ligands of these receptors activates intracellular signaling cascades that rapidly induce the expression of a variety of overlapping and unique genes involved in the inflammatory and immune responses. New insights into innate immunity are changing the way we think about pathogenesis and the treatment of infectious diseases, allergy, and autoimmunity.

@article{citeulike:970694, abstract = {Microorganisms that invade a vertebrate host are initially recognized by the innate immune system through germline-encoded pattern-recognition receptors (PRRs). Several classes of PRRs, including Toll-like receptors and cytoplasmic receptors, recognize distinct microbial components and directly activate immune cells. Exposure of immune cells to the ligands of these receptors activates intracellular signaling cascades that rapidly induce the expression of a variety of overlapping and unique genes involved in the inflammatory and immune responses. New insights into innate immunity are changing the way we think about pathogenesis and the treatment of infectious diseases, allergy, and autoimmunity.}, address = {Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan. sakira@biken.osaka-u.ac.jp}, author = {Akira, S. and Uematsu, S. and Takeuchi, O. }, citeulike-article-id = {970694}, doi = {10.1016/j.cell.2006.02.015}, issn = {0092-8674}, journal = {Cell}, keywords = {tlrs-general}, month = {February}, number = {4}, pages = {783--801}, posted-at = {2007-06-07 21:35:13}, priority = {2}, title = {Pathogen recognition and innate immunity.}, url = {http://dx.doi.org/10.1016/j.cell.2006.02.015}, volume = {124}, year = {2006} }

RIS record

TY - JOUR ID - citeulike:970694 L3 - citeulike-article-id:970694 TI - Pathogen recognition and innate immunity. JF - Cell VL - 124 IS - 4 SP - 783 EP - 801 AD - Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan. sakira@biken.osaka-u.ac.jp SN - 0092-8674 N2 - Microorganisms that invade a vertebrate host are initially recognized by the innate immune system through germline-encoded pattern-recognition receptors (PRRs). Several classes of PRRs, including Toll-like receptors and cytoplasmic receptors, recognize distinct microbial components and directly activate immune cells. Exposure of immune cells to the ligands of these receptors activates intracellular signaling cascades that rapidly induce the expression of a variety of overlapping and unique genes involved in the inflammatory and immune responses. New insights into innate immunity are changing the way we think about pathogenesis and the treatment of infectious diseases, allergy, and autoimmunity. KW - tlrs-general AU - Akira, S AU - Uematsu, S AU - Takeuchi, O PY - 2006/02/24/ UR - http://dx.doi.org/10.1016/j.cell.2006.02.015 ER -

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