Interleukin 25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract.

@article{citeulike:583876, abstract = {The cytokine interleukin (IL) 25 has been implicated in the initiation of type 2 immunity by driving the expression of type 2 cytokines such as IL-5 and IL-13, although its role in the regulation of immunity and infection-induced inflammation is unknown. Here, we identify a dual function for IL-25: first, in promoting type 2 cytokine-dependent immunity to gastrointestinal helminth infection and, second, in limiting proinflammatory cytokine production and chronic intestinal inflammation. Treatment of genetically susceptible mice with exogenous IL-25 promoted type 2 cytokine responses and immunity to Trichuris. IL-25 was constitutively expressed by CD4(+) and CD8(+) T cells in the gut of mouse strains that are resistant to Trichuris, and IL-25-deficient mice on a genetically resistant background failed to develop a type 2 immune response or eradicate infection. Furthermore, chronically infected IL-25(-/-) mice developed severe infection-induced intestinal inflammation associated with heightened expression of interferon-gamma and IL-17, identifying a role for IL-25 in limiting pathologic inflammation at mucosal sites. Therefore, IL-25 is not only a critical mediator of type 2 immunity, but is also required for the regulation of inflammation in the gastrointestinal tract.}, address = {Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104.}, author = {Owyang, Alexander M M. and Zaph, Colby and Wilson, Emma H H. and Guild, Katherine J J. and McClanahan, Terrill and Miller, Hugh R P R. and Cua, Daniel J J. and Goldschmidt, Michael and Hunter, Christopher A A. and Kastelein, Robert A A. and Artis, David }, citeulike-article-id = {583876}, doi = {http://dx.doi.org/10.1084/jem.20051496}, issn = {0022-1007}, journal = {J Exp Med}, keywords = {colitis, crohn, il-25, th2}, month = {April}, posted-at = {2006-04-12 14:47:28}, priority = {2}, title = {Interleukin 25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract.}, url = {http://dx.doi.org/10.1084/jem.20051496}, year = {2006} }

TY - JOUR ID - citeulike:583876 L3 - citeulike-article-id:583876 TI - Interleukin 25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract. JF - J Exp Med AD - Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104. SN - 0022-1007 N2 - The cytokine interleukin (IL) 25 has been implicated in the initiation of type 2 immunity by driving the expression of type 2 cytokines such as IL-5 and IL-13, although its role in the regulation of immunity and infection-induced inflammation is unknown. Here, we identify a dual function for IL-25: first, in promoting type 2 cytokine-dependent immunity to gastrointestinal helminth infection and, second, in limiting proinflammatory cytokine production and chronic intestinal inflammation. Treatment of genetically susceptible mice with exogenous IL-25 promoted type 2 cytokine responses and immunity to Trichuris. IL-25 was constitutively expressed by CD4(+) and CD8(+) T cells in the gut of mouse strains that are resistant to Trichuris, and IL-25-deficient mice on a genetically resistant background failed to develop a type 2 immune response or eradicate infection. Furthermore, chronically infected IL-25(-/-) mice developed severe infection-induced intestinal inflammation associated with heightened expression of interferon-gamma and IL-17, identifying a role for IL-25 in limiting pathologic inflammation at mucosal sites. Therefore, IL-25 is not only a critical mediator of type 2 immunity, but is also required for the regulation of inflammation in the gastrointestinal tract. KW - colitis KW - crohn KW - il-25 KW - th2 AU - Owyang, Alexander M AU - Zaph, Colby AU - Wilson, Emma H AU - Guild, Katherine J AU - McClanahan, Terrill AU - Miller, Hugh R P AU - Cua, Daniel J AU - Goldschmidt, Michael AU - Hunter, Christopher A AU - Kastelein, Robert A AU - Artis, David PY - 2006/04/10/ UR - http://dx.doi.org/10.1084/jem.20051496 ER -