Why do we sleep?

by: TJ Sejnowski, A Destexhe

Brain Res, Vol. 886, No. 1-2. (15 December 2000), pp. 208-223.

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Abstract

Slow-wave sleep consists in slowly recurring waves that are associated with a large-scale spatio-temporal synchrony across neocortex. These slow-wave complexes alternate with brief episodes of fast oscillations, similar to the sustained fast oscillations that occur during the wake state. We propose that alternating fast and slow waves consolidate information acquired previously during wakefulness. Slow-wave sleep would thus begin with spindle oscillations that open molecular gates to plasticity, then proceed by iteratively 'recalling' and 'storing' information primed in neural assemblies. This scenario provides a biophysical mechanism consistent with the growing evidence that sleep serves to consolidate memories.

@article{citeulike:620201, abstract = {Slow-wave sleep consists in slowly recurring waves that are associated with a large-scale spatio-temporal synchrony across neocortex. These slow-wave complexes alternate with brief episodes of fast oscillations, similar to the sustained fast oscillations that occur during the wake state. We propose that alternating fast and slow waves consolidate information acquired previously during wakefulness. Slow-wave sleep would thus begin with spindle oscillations that open molecular gates to plasticity, then proceed by iteratively 'recalling' and 'storing' information primed in neural assemblies. This scenario provides a biophysical mechanism consistent with the growing evidence that sleep serves to consolidate memories.}, address = {Howard Hughes Medical Institute and the Salk Institute, 10010 North Torrey Pines Road, 92037, La Jolla, CA, USA. terry@salk.edu}, author = {Sejnowski, T. J. and Destexhe, A. }, citeulike-article-id = {620201}, issn = {0006-8993}, journal = {Brain Res}, keywords = {cortex, oscilaltions, sleep, thalamus}, month = {December}, number = {1-2}, pages = {208--223}, posted-at = {2006-05-09 09:34:15}, priority = {2}, title = {Why do we sleep?}, url = {http://view.ncbi.nlm.nih.gov/pubmed/11119697}, volume = {886}, year = {2000} }

RIS record

TY - JOUR ID - citeulike:620201 L3 - citeulike-article-id:620201 TI - Why do we sleep? JF - Brain Res VL - 886 IS - 1-2 SP - 208 EP - 223 AD - Howard Hughes Medical Institute and the Salk Institute, 10010 North Torrey Pines Road, 92037, La Jolla, CA, USA. terry@salk.edu SN - 0006-8993 N2 - Slow-wave sleep consists in slowly recurring waves that are associated with a large-scale spatio-temporal synchrony across neocortex. These slow-wave complexes alternate with brief episodes of fast oscillations, similar to the sustained fast oscillations that occur during the wake state. We propose that alternating fast and slow waves consolidate information acquired previously during wakefulness. Slow-wave sleep would thus begin with spindle oscillations that open molecular gates to plasticity, then proceed by iteratively 'recalling' and 'storing' information primed in neural assemblies. This scenario provides a biophysical mechanism consistent with the growing evidence that sleep serves to consolidate memories. KW - cortex KW - oscilaltions KW - sleep KW - thalamus AU - Sejnowski, TJ AU - Destexhe, A PY - 2000/12/15/ UR - http://view.ncbi.nlm.nih.gov/pubmed/11119697 ER -

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