RNA folding at elementary step resolution.

by: C Flamm, W Fontana, IL Hofacker, P Schuster

RNA, Vol. 6, No. 3. (March 2000), pp. 325-338.

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Abstract

We study the stochastic folding kinetics of RNA sequences into secondary structures with a new algorithm based on the formation, dissociation, and the shifting of individual base pairs. We discuss folding mechanisms and the correlation between the barrier structure of the conformational landscape and the folding kinetics for a number of examples based on artificial and natural sequences, including the influence of base modification in tRNAs.

@article{flamm00, abstract = {We study the stochastic folding kinetics of RNA sequences into secondary structures with a new algorithm based on the formation, dissociation, and the shifting of individual base pairs. We discuss folding mechanisms and the correlation between the barrier structure of the conformational landscape and the folding kinetics for a number of examples based on artificial and natural sequences, including the influence of base modification in tRNAs.}, address = {Institut f\"{u}r Theoretische Chemie und Molekulare Strukturbiologie, Universit\"{a}t Wien, Austria. xtof@tbi.univie.ac.at}, author = {Flamm, C. and Fontana, W. and Hofacker, I. L. and Schuster, P. }, citeulike-article-id = {613296}, issn = {1355-8382}, journal = {RNA}, keywords = {folding, kinetics, kinfold, rna}, month = {March}, number = {3}, pages = {325--338}, posted-at = {2008-04-15 16:44:38}, priority = {0}, title = {RNA folding at elementary step resolution.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/10744018}, volume = {6}, year = {2000} }

RIS record

TY - JOUR ID - flamm00 L3 - citeulike-article-id:613296 TI - RNA folding at elementary step resolution. JF - RNA VL - 6 IS - 3 SP - 325 EP - 338 AD - Institut für Theoretische Chemie und Molekulare Strukturbiologie, Universität Wien, Austria. xtof@tbi.univie.ac.at SN - 1355-8382 N2 - We study the stochastic folding kinetics of RNA sequences into secondary structures with a new algorithm based on the formation, dissociation, and the shifting of individual base pairs. We discuss folding mechanisms and the correlation between the barrier structure of the conformational landscape and the folding kinetics for a number of examples based on artificial and natural sequences, including the influence of base modification in tRNAs. KW - folding KW - kinetics KW - kinfold KW - rna AU - Flamm, C AU - Fontana, W AU - Hofacker, IL AU - Schuster, P PY - 2000/03// UR - http://view.ncbi.nlm.nih.gov/pubmed/10744018 ER -

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