Dendritic mechanisms controlling spike-timing-dependent synaptic plasticity.

@article{citeulike:2869854, abstract = {The ability of neurons to modulate the strength of their synaptic connections has been shown to depend on the relative timing of pre- and postsynaptic action potentials. This form of synaptic plasticity, called spike-timing-dependent plasticity (STDP), has become an attractive model for learning at the single-cell level. Yet, despite its popularity in experimental and theoretical neuroscience, the influence of dendritic mechanisms in the induction of STDP has been largely overlooked. Several recent studies have investigated how active dendritic properties and synapse location within the dendritic tree influence STDP. These studies suggest the existence of learning rules that depend on firing mode and subcellular input location, adding unanticipated complexity to STDP. Here, we propose a new look at STDP that is focused on processing at the postsynaptic site in the dendrites, rather than on spike-timing at the cell body.}, address = {Brain Research Institute, University of Z\"{u}rich, Winterthurerstr. 190, 8057 Z\"{u}rich, Switzerland. kampa@hifo.unizh.ch}, author = {Kampa, B. M. and Letzkus, J. J. and Stuart, G. J. }, citeulike-article-id = {2869854}, doi = {http://dx.doi.org/10.1016/j.tins.2007.06.010}, issn = {0166-2236}, journal = {Trends in neurosciences}, keywords = {dendrites, dendritic-spikes, ltp, plasticity, review, stdp}, month = {September}, number = {9}, pages = {456--463}, posted-at = {2008-06-17 16:31:20}, priority = {0}, title = {Dendritic mechanisms controlling spike-timing-dependent synaptic plasticity.}, url = {http://dx.doi.org/10.1016/j.tins.2007.06.010}, volume = {30}, year = {2007} }

TY - JOUR ID - citeulike:2869854 L3 - citeulike-article-id:2869854 TI - Dendritic mechanisms controlling spike-timing-dependent synaptic plasticity. JF - Trends in neurosciences VL - 30 IS - 9 SP - 456 EP - 463 AD - Brain Research Institute, University of Zürich, Winterthurerstr. 190, 8057 Zürich, Switzerland. kampa@hifo.unizh.ch SN - 0166-2236 N2 - The ability of neurons to modulate the strength of their synaptic connections has been shown to depend on the relative timing of pre- and postsynaptic action potentials. This form of synaptic plasticity, called spike-timing-dependent plasticity (STDP), has become an attractive model for learning at the single-cell level. Yet, despite its popularity in experimental and theoretical neuroscience, the influence of dendritic mechanisms in the induction of STDP has been largely overlooked. Several recent studies have investigated how active dendritic properties and synapse location within the dendritic tree influence STDP. These studies suggest the existence of learning rules that depend on firing mode and subcellular input location, adding unanticipated complexity to STDP. Here, we propose a new look at STDP that is focused on processing at the postsynaptic site in the dendrites, rather than on spike-timing at the cell body. KW - dendrites KW - dendritic-spikes KW - ltp KW - plasticity KW - review KW - stdp AU - Kampa, BM AU - Letzkus, JJ AU - Stuart, GJ PY - 2007/09// UR - http://dx.doi.org/10.1016/j.tins.2007.06.010 ER -