The use of logic relationships to model colon cancer gene expression networks with mRNA microarray data.

@article{citeulike:3014350, abstract = {The ultimate goal of genomics research is to describe the network of molecules and interactions that govern all biological functions and disease processes in cells. Nonlinear interactions among genes in terms of their logic relationships play a key role for deciphering the networks of molecules that underlie cellular function. We present a method based on a graph coloring scheme and information theory to identify the gene expression network with lower and higher order logic interactions of genes. The analysis of oncogenes and suppressor genes from a colon cancer mRNA microarray dataset identifies a gene expression network with directionality and weights that reflects intracellular communication pathways. The success of the proposed method in mining hidden, complicated gene interactions and reliably interpreting experimental results suggests that the proposed method is a useful tool for understanding cancer systems. Extension of this method holds the potential to be fruitful for understanding other complex, nonsymmetric systems.}, address = {College of Electronic Information and Control Engineering, Beijing University of Technology, Pingleyuan 100\#, Chaoyang District 100022, PR China. adrxg@bjut.edu.cn}, author = {Ruan, X. and Wang, J. and Li, H. and Perozzi, R. E. and Perozzi, E. F. }, citeulike-article-id = {3014350}, doi = {http://dx.doi.org/10.1016/j.jbi.2007.11.006}, issn = {1532-0480}, journal = {Journal of biomedical informatics}, keywords = {biological-inspired-modeling, cell-models, diseaseomics, gene-expression, gene-gene, genome-interactome, modeling-and-simulation, networks, rna}, month = {August}, number = {4}, pages = {530--543}, posted-at = {2008-07-17 15:12:17}, priority = {2}, title = {The use of logic relationships to model colon cancer gene expression networks with mRNA microarray data.}, url = {http://dx.doi.org/10.1016/j.jbi.2007.11.006}, volume = {41}, year = {2008} }

TY - JOUR ID - citeulike:3014350 L3 - citeulike-article-id:3014350 TI - The use of logic relationships to model colon cancer gene expression networks with mRNA microarray data. JF - Journal of biomedical informatics VL - 41 IS - 4 SP - 530 EP - 543 AD - College of Electronic Information and Control Engineering, Beijing University of Technology, Pingleyuan 100#, Chaoyang District 100022, PR China. adrxg@bjut.edu.cn SN - 1532-0480 N2 - The ultimate goal of genomics research is to describe the network of molecules and interactions that govern all biological functions and disease processes in cells. Nonlinear interactions among genes in terms of their logic relationships play a key role for deciphering the networks of molecules that underlie cellular function. We present a method based on a graph coloring scheme and information theory to identify the gene expression network with lower and higher order logic interactions of genes. The analysis of oncogenes and suppressor genes from a colon cancer mRNA microarray dataset identifies a gene expression network with directionality and weights that reflects intracellular communication pathways. The success of the proposed method in mining hidden, complicated gene interactions and reliably interpreting experimental results suggests that the proposed method is a useful tool for understanding cancer systems. Extension of this method holds the potential to be fruitful for understanding other complex, nonsymmetric systems. KW - biological-inspired-modeling KW - cell-models KW - diseaseomics KW - gene-expression KW - gene-gene KW - genome-interactome KW - modeling-and-simulation KW - networks KW - rna AU - Ruan, X AU - Wang, J AU - Li, H AU - Perozzi, RE AU - Perozzi, EF PY - 2008/08// UR - http://dx.doi.org/10.1016/j.jbi.2007.11.006 ER -