Cell and environment interactions in tumor microregions: the multicell spheroid model.

by: RM Sutherland

Science (New York, N.Y.), Vol. 240, No. 4849. (8 April 1988), pp. 177-184.

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Abstract

Abnormal vascularization of malignant tumors is associated with the development of microregions of heterogeneous cells and environments. Experimental models such as multicell spheroids and a variety of new techniques are being used to determine the characteristics of these microregions and to study the interactions of the cells and microenvironments. The special cellular microecology of tumors influences responsiveness to therapeutic agents and has implications for future directions in cancer research.

@article{citeulike:3046628, abstract = {Abnormal vascularization of malignant tumors is associated with the development of microregions of heterogeneous cells and environments. Experimental models such as multicell spheroids and a variety of new techniques are being used to determine the characteristics of these microregions and to study the interactions of the cells and microenvironments. The special cellular microecology of tumors influences responsiveness to therapeutic agents and has implications for future directions in cancer research.}, address = {Cancer Center for Experimental Therapeutics, University of Rochester School of Medicine and Dentistry, NY 14642.}, author = {Sutherland, R. M. }, citeulike-article-id = {3046628}, issn = {0036-8075}, journal = {Science (New York, N.Y.)}, keywords = {cell-models, ecophysiology, gene-gene, genome-interactome, genotype-to-phenotype, systems-biology}, month = {April}, number = {4849}, pages = {177--184}, posted-at = {2008-07-28 01:31:07}, priority = {2}, title = {Cell and environment interactions in tumor microregions: the multicell spheroid model.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/2451290}, volume = {240}, year = {1988} }

RIS record

TY - JOUR ID - citeulike:3046628 L3 - citeulike-article-id:3046628 TI - Cell and environment interactions in tumor microregions: the multicell spheroid model. JF - Science (New York, N.Y.) VL - 240 IS - 4849 SP - 177 EP - 184 AD - Cancer Center for Experimental Therapeutics, University of Rochester School of Medicine and Dentistry, NY 14642. SN - 0036-8075 N2 - Abnormal vascularization of malignant tumors is associated with the development of microregions of heterogeneous cells and environments. Experimental models such as multicell spheroids and a variety of new techniques are being used to determine the characteristics of these microregions and to study the interactions of the cells and microenvironments. The special cellular microecology of tumors influences responsiveness to therapeutic agents and has implications for future directions in cancer research. KW - cell-models KW - ecophysiology KW - gene-gene KW - genome-interactome KW - genotype-to-phenotype KW - systems-biology AU - Sutherland, RM PY - 1988/04/08/ UR - http://view.ncbi.nlm.nih.gov/pubmed/2451290 ER -

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