Tumor cells convert immature myeloid dendritic cells into TGF-beta-secreting cells inducing CD4+CD25+ regulatory T cell proliferation.

@article{citeulike:375379, abstract = {The mechanisms through which regulatory T cells accumulate in lymphoid organs of tumor-bearing hosts remain elusive. Our experiments indicate that the accumulation of CD4(+)CD25(+) regulatory T cells (T reg cells) expressing FoxP3 and exhibiting immunosuppressive function originates from the proliferation of naturally occurring CD25(+) T cells and requires signaling through transforming growth factor (TGF)-beta receptor II. During tumor progression, a subset of dendritic cells (DCs) exhibiting a myeloid immature phenotype is recruited to draining lymph nodes. This DC subset selectively promotes the proliferation of T reg cells in a TGF-beta-dependent manner in mice and rats. Tumor cells are necessary and sufficient to convert DCs into regulatory cells that secrete bioactive TGF-beta and stimulate T reg cell proliferation. In conclusion, tumor expansion can stimulate T reg cells via a specific DC subset.}, address = {Institut National de la Sant\'{e} et de la Recherche M\'{e}dicale, U517, University of Burgundy, 21079 Dijon, France.}, author = {Ghiringhelli, F. and Puig, P. E. and Roux, S. and Parcellier, A. and Schmitt, E. and Solary, E. and Kroemer, G. and Martin, F. and Chauffert, B. and Zitvogel, L. }, citeulike-article-id = {375379}, doi = {10.1084/jem.20050463}, issn = {0022-1007}, journal = {J Exp Med}, keywords = {cell, dendritic, tgf-beta, treg, tumor}, month = {October}, number = {7}, pages = {919--929}, posted-at = {2007-09-22 22:34:37}, priority = {3}, title = {Tumor cells convert immature myeloid dendritic cells into TGF-{beta}-secreting cells inducing CD4+CD25+ regulatory T cell proliferation.}, url = {http://dx.doi.org/10.1084/jem.20050463}, volume = {202}, year = {2005} }

TY - JOUR ID - citeulike:375379 L3 - citeulike-article-id:375379 TI - Tumor cells convert immature myeloid dendritic cells into TGF-{beta}-secreting cells inducing CD4+CD25+ regulatory T cell proliferation. JF - J Exp Med VL - 202 IS - 7 SP - 919 EP - 929 AD - Institut National de la Santé et de la Recherche Médicale, U517, University of Burgundy, 21079 Dijon, France. SN - 0022-1007 N2 - The mechanisms through which regulatory T cells accumulate in lymphoid organs of tumor-bearing hosts remain elusive. Our experiments indicate that the accumulation of CD4(+)CD25(+) regulatory T cells (T reg cells) expressing FoxP3 and exhibiting immunosuppressive function originates from the proliferation of naturally occurring CD25(+) T cells and requires signaling through transforming growth factor (TGF)-beta receptor II. During tumor progression, a subset of dendritic cells (DCs) exhibiting a myeloid immature phenotype is recruited to draining lymph nodes. This DC subset selectively promotes the proliferation of T reg cells in a TGF-beta-dependent manner in mice and rats. Tumor cells are necessary and sufficient to convert DCs into regulatory cells that secrete bioactive TGF-beta and stimulate T reg cell proliferation. In conclusion, tumor expansion can stimulate T reg cells via a specific DC subset. KW - cell KW - dendritic KW - tgf-beta KW - treg KW - tumor AU - Ghiringhelli, F AU - Puig, PE AU - Roux, S AU - Parcellier, A AU - Schmitt, E AU - Solary, E AU - Kroemer, G AU - Martin, F AU - Chauffert, B AU - Zitvogel, L PY - 2005/10/03/ UR - http://dx.doi.org/10.1084/jem.20050463 ER -