Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants.

@article{citeulike:418576, abstract = {Various chronic antidepressant treatments increase adult hippocampal neurogenesis, but the functional importance of this phenomenon remains unclear. Here, using genetic and radiological methods, we show that disrupting antidepressant-induced neurogenesis blocks behavioral responses to antidepressants. Serotonin 1A receptor null mice were insensitive to the neurogenic and behavioral effects of fluoxetine, a serotonin selective reuptake inhibitor. X-irradiation of a restricted region of mouse brain containing the hippocampus prevented the neurogenic and behavioral effects of two classes of antidepressants. These findings suggest that the behavioral effects of chronic antidepressants may be mediated by the stimulation of neurogenesis in the hippocampus.}, address = {Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA.}, author = {Santarelli, L. and Saxe, M. and Gross, C. and Surget, A. and Battaglia, F. and Dulawa, S. and Weisstaub, N. and Lee, J. and Duman, R. and Arancio, O. and Belzung, C. and Hen, R. }, citeulike-article-id = {418576}, doi = {http://dx.doi.org/10.1126/science.1083328}, issn = {1095-9203}, journal = {Science}, keywords = {anxiety, nsf}, month = {August}, number = {5634}, pages = {805--809}, posted-at = {2008-06-10 20:00:57}, priority = {2}, title = {Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants.}, url = {http://dx.doi.org/10.1126/science.1083328}, volume = {301}, year = {2003} }

TY - JOUR ID - citeulike:418576 L3 - citeulike-article-id:418576 TI - Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. JF - Science VL - 301 IS - 5634 SP - 805 EP - 809 AD - Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA. SN - 1095-9203 N2 - Various chronic antidepressant treatments increase adult hippocampal neurogenesis, but the functional importance of this phenomenon remains unclear. Here, using genetic and radiological methods, we show that disrupting antidepressant-induced neurogenesis blocks behavioral responses to antidepressants. Serotonin 1A receptor null mice were insensitive to the neurogenic and behavioral effects of fluoxetine, a serotonin selective reuptake inhibitor. X-irradiation of a restricted region of mouse brain containing the hippocampus prevented the neurogenic and behavioral effects of two classes of antidepressants. These findings suggest that the behavioral effects of chronic antidepressants may be mediated by the stimulation of neurogenesis in the hippocampus. KW - anxiety KW - nsf AU - Santarelli, L AU - Saxe, M AU - Gross, C AU - Surget, A AU - Battaglia, F AU - Dulawa, S AU - Weisstaub, N AU - Lee, J AU - Duman, R AU - Arancio, O AU - Belzung, C AU - Hen, R PY - 2003/08/08/ UR - http://dx.doi.org/10.1126/science.1083328 ER -