G-ribo: A new structural motif in ribosomal RNA

by: Sergey V Steinberg, Yury I Boutorine

RNA, Vol. 13, No. 4. (1 April 2007), pp. 549-554.

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Abstract

Analysis of the available crystal structures of the ribosome and of its subunits has revealed a new RNA motif that we call G-ribo. The motif consists of two double helices positioned side-by-side and connected by an unpaired region. The juxtaposition of the two helices is kept by a complex system of tertiary interactions spread over several layers of stacked nucleotides. In the center of this arrangement, the ribose of a nucleotide from one helix is specifically packed with the ribose and the minor-groove edge of a guanosine from the other helix. In total, we found eight G-ribo motifs in both ribosomal subunits. The location of these motifs suggests that at least some of them play an important role in the formation of the ribosome structure and/or in its function. 10.1261/rna.387107

@article{steinberg-bouterine-07, abstract = {Analysis of the available crystal structures of the ribosome and of its subunits has revealed a new RNA motif that we call G-ribo. The motif consists of two double helices positioned side-by-side and connected by an unpaired region. The juxtaposition of the two helices is kept by a complex system of tertiary interactions spread over several layers of stacked nucleotides. In the center of this arrangement, the ribose of a nucleotide from one helix is specifically packed with the ribose and the minor-groove edge of a guanosine from the other helix. In total, we found eight G-ribo motifs in both ribosomal subunits. The location of these motifs suggests that at least some of them play an important role in the formation of the ribosome structure and/or in its function. 10.1261/rna.387107}, author = {Steinberg, Sergey V. and Boutorine, Yury I. }, citeulike-article-id = {1182168}, journal = {RNA}, keywords = {rna, structure, tertiary}, month = {April}, number = {4}, pages = {549--554}, posted-at = {2007-03-23 23:50:17}, priority = {2}, title = {G-ribo: A new structural motif in ribosomal RNA}, url = {http://www.rnajournal.org/cgi/content/abstract/13/4/549}, volume = {13}, year = {2007} }

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TY - JOUR ID - steinberg-bouterine-07 L3 - citeulike-article-id:1182168 TI - G-ribo: A new structural motif in ribosomal RNA JF - RNA VL - 13 IS - 4 SP - 549 EP - 554 N2 - Analysis of the available crystal structures of the ribosome and of its subunits has revealed a new RNA motif that we call G-ribo. The motif consists of two double helices positioned side-by-side and connected by an unpaired region. The juxtaposition of the two helices is kept by a complex system of tertiary interactions spread over several layers of stacked nucleotides. In the center of this arrangement, the ribose of a nucleotide from one helix is specifically packed with the ribose and the minor-groove edge of a guanosine from the other helix. In total, we found eight G-ribo motifs in both ribosomal subunits. The location of these motifs suggests that at least some of them play an important role in the formation of the ribosome structure and/or in its function. 10.1261/rna.387107 KW - rna KW - structure KW - tertiary AU - Steinberg, Sergey AU - Boutorine, Yury PY - 2007/04/01/ UR - http://www.rnajournal.org/cgi/content/abstract/13/4/549 ER -

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