Combinatorics of feedback in cellular uptake and metabolism of small molecules

@article{citeulike:2157950, abstract = {We analyze the connection between structure and function for regulatory motifs associated with cellular uptake and usage of small molecules. Based on the boolean logic of the feedback we suggest four classes: the socialist, consumer, fashion, and collector motifs. We find that the socialist motif is good for homeostasis of a useful but potentially poisonous molecule, whereas the consumer motif is optimal for nutrition molecules. Accordingly, examples of these motifs are found in, respectively, the iron homeostasis system in various organisms and in the uptake of sugar molecules in bacteria. The remaining two motifs have no obvious analogs in small molecule regulation, but we illustrate their behavior using analogies to fashion and obesity. These extreme motifs could inspire construction of synthetic systems that exhibit bistable, history-dependent states, and homeostasis of flux (rather than concentration). 10.1073/pnas.0706231105}, author = {Krishna, Sandeep and Semsey, Szabolcs and Sneppen, Kim }, citeulike-article-id = {2157950}, doi = {http://dx.doi.org/10.1073/pnas.0706231105}, journal = {Proceedings of the National Academy of Sciences}, keywords = {biomath}, month = {December}, pages = {0706231105+}, posted-at = {2007-12-27 05:25:02}, priority = {2}, title = {Combinatorics of feedback in cellular uptake and metabolism of small molecules}, url = {http://dx.doi.org/10.1073/pnas.0706231105}, year = {2007} }

TY - JOUR ID - citeulike:2157950 L3 - citeulike-article-id:2157950 TI - Combinatorics of feedback in cellular uptake and metabolism of small molecules JF - Proceedings of the National Academy of Sciences SP - 0706231105 N2 - We analyze the connection between structure and function for regulatory motifs associated with cellular uptake and usage of small molecules. Based on the boolean logic of the feedback we suggest four classes: the socialist, consumer, fashion, and collector motifs. We find that the socialist motif is good for homeostasis of a useful but potentially poisonous molecule, whereas the consumer motif is optimal for nutrition molecules. Accordingly, examples of these motifs are found in, respectively, the iron homeostasis system in various organisms and in the uptake of sugar molecules in bacteria. The remaining two motifs have no obvious analogs in small molecule regulation, but we illustrate their behavior using analogies to fashion and obesity. These extreme motifs could inspire construction of synthetic systems that exhibit bistable, history-dependent states, and homeostasis of flux (rather than concentration). 10.1073/pnas.0706231105 KW - biomath AU - Krishna, Sandeep AU - Semsey, Szabolcs AU - Sneppen, Kim PY - 2007/12/19/ UR - http://dx.doi.org/10.1073/pnas.0706231105 ER -