Partial protection against infectious bursal disease virus through DNA-mediated vaccination with the VP2 capsid protein and chicken IL-2 genes.

by: DJ Hulse, CH Romero

Vaccine, Vol. 22, No. 9-10. (12 March 2004), pp. 1249-1259.

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Abstract

Several DNA vaccination experiments were performed to determine the protective capability of a plasmid DNA molecule encoding the VP2 capsid protein gene of infectious bursal disease virus (IBDV) injected into chickens in the presence or absence of chicken interleukin 2 (IL-2) plasmid DNA. The results of these experiments indicate that partial protection against IBDV can be achieved by using the VP2 gene of IBDV as a DNA vaccine. Furthermore, the simultaneous injection of chicken IL-2 plasmid DNA significantly increased the protection after challenge with the virulent strain. It was also found that immunological tolerance may have been induced in one of the chicken experiments by vaccination with plasmid DNA.

@article{citeulike:1234659, abstract = {Several DNA vaccination experiments were performed to determine the protective capability of a plasmid DNA molecule encoding the VP2 capsid protein gene of infectious bursal disease virus (IBDV) injected into chickens in the presence or absence of chicken interleukin 2 (IL-2) plasmid DNA. The results of these experiments indicate that partial protection against IBDV can be achieved by using the VP2 gene of IBDV as a DNA vaccine. Furthermore, the simultaneous injection of chicken IL-2 plasmid DNA significantly increased the protection after challenge with the virulent strain. It was also found that immunological tolerance may have been induced in one of the chicken experiments by vaccination with plasmid DNA.}, address = {Department of Pathobiology, University of Florida, 2015 SW 16th Ave. Gainesville, FL 32611, USA. diane.hulse@stjude.org}, author = {Hulse, D. J. and Romero, C. H. }, citeulike-article-id = {1234659}, doi = {10.1016/j.vaccine.2003.09.021}, issn = {0264-410X}, journal = {Vaccine}, keywords = {cytokine, ibdv, vaccine}, month = {March}, number = {9-10}, pages = {1249--1259}, posted-at = {2007-04-18 19:02:34}, priority = {3}, title = {Partial protection against infectious bursal disease virus through DNA-mediated vaccination with the VP2 capsid protein and chicken IL-2 genes.}, url = {http://dx.doi.org/10.1016/j.vaccine.2003.09.021}, volume = {22}, year = {2004} }

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TY - JOUR ID - citeulike:1234659 L3 - citeulike-article-id:1234659 TI - Partial protection against infectious bursal disease virus through DNA-mediated vaccination with the VP2 capsid protein and chicken IL-2 genes. JF - Vaccine VL - 22 IS - 9-10 SP - 1249 EP - 1259 AD - Department of Pathobiology, University of Florida, 2015 SW 16th Ave. Gainesville, FL 32611, USA. diane.hulse@stjude.org SN - 0264-410X N2 - Several DNA vaccination experiments were performed to determine the protective capability of a plasmid DNA molecule encoding the VP2 capsid protein gene of infectious bursal disease virus (IBDV) injected into chickens in the presence or absence of chicken interleukin 2 (IL-2) plasmid DNA. The results of these experiments indicate that partial protection against IBDV can be achieved by using the VP2 gene of IBDV as a DNA vaccine. Furthermore, the simultaneous injection of chicken IL-2 plasmid DNA significantly increased the protection after challenge with the virulent strain. It was also found that immunological tolerance may have been induced in one of the chicken experiments by vaccination with plasmid DNA. KW - cytokine KW - ibdv KW - vaccine AU - Hulse, DJ AU - Romero, CH PY - 2004/03/12/ UR - http://dx.doi.org/10.1016/j.vaccine.2003.09.021 ER -

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