The cell as a material

by: Karen E Kasza, Amy C Rowat, Jiayu Liu, Thomas E Angelini, Clifford P Brangwynne, Gijsje H Koenderink, David A Weitz

Current Opinion in Cell Biology, Vol. 19, No. 1. (February 2007), pp. 101-107.

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Abstract

To elucidate the dynamic and functional role of a cell within the tissue it belongs to, it is essential to understand its material properties. The cell is a viscoelastic material with highly unusual properties. Measurements of the mechanical behavior of cells are beginning to probe the contribution of constituent components to cell mechanics. Reconstituted cytoskeletal protein networks have been shown to mimic many aspects of the mechanical properties of cells, providing new insight into the origin of cellular behavior. These networks are highly nonlinear, with an elastic modulus that depends sensitively on applied stress. Theories can account for some of the measured properties, but a complete model remains elusive.

@article{citeulike:2688177, abstract = {To elucidate the dynamic and functional role of a cell within the tissue it belongs to, it is essential to understand its material properties. The cell is a viscoelastic material with highly unusual properties. Measurements of the mechanical behavior of cells are beginning to probe the contribution of constituent components to cell mechanics. Reconstituted cytoskeletal protein networks have been shown to mimic many aspects of the mechanical properties of cells, providing new insight into the origin of cellular behavior. These networks are highly nonlinear, with an elastic modulus that depends sensitively on applied stress. Theories can account for some of the measured properties, but a complete model remains elusive.}, author = {Kasza, Karen E. and Rowat, Amy C. and Liu, Jiayu and Angelini, Thomas E. and Brangwynne, Clifford P. and Koenderink, Gijsje H. and Weitz, David A. }, booktitle = {Cell structure and dynamics}, citeulike-article-id = {2688177}, doi = {10.1016/j.ceb.2006.12.002}, journal = {Current Opinion in Cell Biology}, keywords = {biology, review, weitz}, month = {February}, number = {1}, pages = {101--107}, posted-at = {2008-04-18 16:28:03}, priority = {2}, title = {The cell as a material}, url = {http://dx.doi.org/10.1016/j.ceb.2006.12.002}, volume = {19}, year = {2007} }

RIS record

TY - JOUR ID - citeulike:2688177 TI - The cell as a material T2 - Cell structure and dynamics JF - Current Opinion in Cell Biology VL - 19 IS - 1 SP - 101 EP - 107 N2 - To elucidate the dynamic and functional role of a cell within the tissue it belongs to, it is essential to understand its material properties. The cell is a viscoelastic material with highly unusual properties. Measurements of the mechanical behavior of cells are beginning to probe the contribution of constituent components to cell mechanics. Reconstituted cytoskeletal protein networks have been shown to mimic many aspects of the mechanical properties of cells, providing new insight into the origin of cellular behavior. These networks are highly nonlinear, with an elastic modulus that depends sensitively on applied stress. Theories can account for some of the measured properties, but a complete model remains elusive. KW - biology KW - review KW - weitz AU - Kasza, Karen AU - Rowat, Amy AU - Liu, Jiayu AU - Angelini, Thomas AU - Brangwynne, Clifford AU - Koenderink, Gijsje AU - Weitz, David PY - 2007/02// UR - http://dx.doi.org/10.1016/j.ceb.2006.12.002 ER -

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