Directed Motion of Proteins along Tethered Polyelectrolytes

by: Katja Henzler, Sabine Rosenfeldt, Alexander Wittemann, Ludger Harnau, Stephanie Finet, Theyencheri Narayanan, Matthias Ballauff

Physical Review Letters, Vol. 100, No. 15. (2008)

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Abstract

We present the first time-resolved investigation of motions of proteins in densely grafted layers of spherical polyelectrolyte brushes. Using small-angle x-ray scattering combined with rapid stopped-flow mixing, we followed the uptake of bovine serum albumin by poly(acrylic acid) layer with high spatial and temporal resolution. We find that the total amount of adsorbed protein scales with time as t1/4. This subdiffusive behavior is explained on the basis of directed motion of the protein along the polyelectrolyte chains.

@article{citeulike:2762175, abstract = {We present the first time-resolved investigation of motions of proteins in densely grafted layers of spherical polyelectrolyte brushes. Using small-angle x-ray scattering combined with rapid stopped-flow mixing, we followed the uptake of bovine serum albumin by poly(acrylic acid) layer with high spatial and temporal resolution. We find that the total amount of adsorbed protein scales with time as t1/4. This subdiffusive behavior is explained on the basis of directed motion of the protein along the polyelectrolyte chains.}, author = {Henzler, Katja and Rosenfeldt, Sabine and Wittemann, Alexander and Harnau, Ludger and Finet, Stephanie and Narayanan, Theyencheri and Ballauff, Matthias }, citeulike-article-id = {2762175}, doi = {10.1103/PhysRevLett.100.158301}, journal = {Physical Review Letters}, keywords = {2008, biology, diffusion, polymer}, number = {15}, posted-at = {2008-05-06 18:58:47}, priority = {2}, publisher = {APS}, title = {Directed Motion of Proteins along Tethered Polyelectrolytes}, url = {http://scitation.aip.org/getabs/servlet/GetabsServlet?prog=normal\&id=PRLTAO000100000015158301000001\&idtype=cvips\&gifs=yes}, volume = {100}, year = {2008} }

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TY - JOUR ID - citeulike:2762175 TI - Directed Motion of Proteins along Tethered Polyelectrolytes JF - Physical Review Letters VL - 100 IS - 15 PB - APS N2 - We present the first time-resolved investigation of motions of proteins in densely grafted layers of spherical polyelectrolyte brushes. Using small-angle x-ray scattering combined with rapid stopped-flow mixing, we followed the uptake of bovine serum albumin by poly(acrylic acid) layer with high spatial and temporal resolution. We find that the total amount of adsorbed protein scales with time as t1/4. This subdiffusive behavior is explained on the basis of directed motion of the protein along the polyelectrolyte chains. KW - 2008 KW - biology KW - diffusion KW - polymer AU - Henzler, Katja AU - Rosenfeldt, Sabine AU - Wittemann, Alexander AU - Harnau, Ludger AU - Finet, Stephanie AU - Narayanan, Theyencheri AU - Ballauff, Matthias PY - 2008/// UR - http://scitation.aip.org/getabs/servlet/GetabsServlet?prog=normal&id=PRLTAO000100000015158301000001&idtype=cvips&gifs=yes ER -

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