ULBP4 is a novel ligand for human NKG2D.

by: NJ Chalupny, CL Sutherland, WA Lawrence, A Rein-Weston, D Cosman

Biochem Biophys Res Commun, Vol. 305, No. 1. (23 May 2003), pp. 129-135.

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Abstract

The ULBPs are a family of MHC class I-related molecules. We have previously shown that ULBPs 1, 2, and 3 are functional ligands of the NKG2D/DAP10 receptor complex on human natural killer (NK) cells. Here, we describe a new member of the ULBP family, ULBP4, which contains predicted transmembrane and cytoplasmic domains, unlike the other ULBPs, which are GPI-linked proteins. Transduction of ULBP4 into EL4 cells confers the ability to bind recombinant NKG2D and mediates increased cytotoxic activity by human NK cells, consistent with the role of ULBPs as ligands for the NKG2D/DAP10 activating receptors. Tissue expression of ULBP4 differs from other members of the family, in that it is expressed predominantly in the skin.

@article{citeulike:1452918, abstract = {The ULBPs are a family of MHC class I-related molecules. We have previously shown that ULBPs 1, 2, and 3 are functional ligands of the NKG2D/DAP10 receptor complex on human natural killer (NK) cells. Here, we describe a new member of the ULBP family, ULBP4, which contains predicted transmembrane and cytoplasmic domains, unlike the other ULBPs, which are GPI-linked proteins. Transduction of ULBP4 into EL4 cells confers the ability to bind recombinant NKG2D and mediates increased cytotoxic activity by human NK cells, consistent with the role of ULBPs as ligands for the NKG2D/DAP10 activating receptors. Tissue expression of ULBP4 differs from other members of the family, in that it is expressed predominantly in the skin.}, address = {Amgen, 51 University St, Seattle, WA 98101, USA.}, author = {Chalupny, N. J. and Sutherland, C. L. and Lawrence, W. A. and Rein-Weston, A. and Cosman, D. }, citeulike-article-id = {1452918}, issn = {0006-291X}, journal = {Biochem Biophys Res Commun}, keywords = {identification, ligands, nkg2d, ulbp, ulbp4}, month = {May}, number = {1}, pages = {129--135}, posted-at = {2007-07-12 21:08:24}, priority = {2}, title = {ULBP4 is a novel ligand for human NKG2D.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/12732206}, volume = {305}, year = {2003} }

RIS record

TY - JOUR ID - citeulike:1452918 L3 - citeulike-article-id:1452918 TI - ULBP4 is a novel ligand for human NKG2D. JF - Biochem Biophys Res Commun VL - 305 IS - 1 SP - 129 EP - 135 AD - Amgen, 51 University St, Seattle, WA 98101, USA. SN - 0006-291X N2 - The ULBPs are a family of MHC class I-related molecules. We have previously shown that ULBPs 1, 2, and 3 are functional ligands of the NKG2D/DAP10 receptor complex on human natural killer (NK) cells. Here, we describe a new member of the ULBP family, ULBP4, which contains predicted transmembrane and cytoplasmic domains, unlike the other ULBPs, which are GPI-linked proteins. Transduction of ULBP4 into EL4 cells confers the ability to bind recombinant NKG2D and mediates increased cytotoxic activity by human NK cells, consistent with the role of ULBPs as ligands for the NKG2D/DAP10 activating receptors. Tissue expression of ULBP4 differs from other members of the family, in that it is expressed predominantly in the skin. KW - identification KW - ligands KW - nkg2d KW - ulbp KW - ulbp4 AU - Chalupny, NJ AU - Sutherland, CL AU - Lawrence, WA AU - Rein-Weston, A AU - Cosman, D PY - 2003/05/23/ UR - http://view.ncbi.nlm.nih.gov/pubmed/12732206 ER -

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