Divergence of Quaternary Structures Among Bacterial Flagellar Filaments

@article{citeulike:2762844, abstract = {It has been widely assumed that the atomic structure of the flagellar filament from Salmonella typhimurium serves as a model for all bacterial flagellar filaments given the sequence conservation in the coiled-coil regions responsible for polymerization. On the basis of electron microscopic images, we show that the flagellar filaments from Campylobacter jejuni have seven protofilaments rather than the 11 in S. typhimurium. The vertebrate Toll-like receptor 5 (TLR5) recognizes a region of bacterial flagellin that is involved in subunit-subunit assembly in Salmonella and many other pathogenic bacteria, and this short region has diverged in Campylobacter and related bacteria, such as Helicobacter pylori, which are not recognized by TLR5. The driving force in the change of quaternary structure between Salmonella and Campylobacter may have been the evasion of TLR5. 10.1126/science.1155307}, author = {Galkin, Vitold E. and Yu, Xiong and Bielnicki, Jakub and Heuser, John and Ewing, Cheryl P. and Guerry, Patricia and Egelman, Edward H. }, citeulike-article-id = {2762844}, doi = {http://dx.doi.org/10.1126/science.1155307}, journal = {Science}, month = {April}, number = {5874}, pages = {382--385}, posted-at = {2008-05-06 21:34:14}, priority = {2}, title = {Divergence of Quaternary Structures Among Bacterial Flagellar Filaments}, url = {http://dx.doi.org/10.1126/science.1155307}, volume = {320}, year = {2008} }

TY - JOUR ID - citeulike:2762844 L3 - citeulike-article-id:2762844 TI - Divergence of Quaternary Structures Among Bacterial Flagellar Filaments JF - Science VL - 320 IS - 5874 SP - 382 EP - 385 N2 - It has been widely assumed that the atomic structure of the flagellar filament from Salmonella typhimurium serves as a model for all bacterial flagellar filaments given the sequence conservation in the coiled-coil regions responsible for polymerization. On the basis of electron microscopic images, we show that the flagellar filaments from Campylobacter jejuni have seven protofilaments rather than the 11 in S. typhimurium. The vertebrate Toll-like receptor 5 (TLR5) recognizes a region of bacterial flagellin that is involved in subunit-subunit assembly in Salmonella and many other pathogenic bacteria, and this short region has diverged in Campylobacter and related bacteria, such as Helicobacter pylori, which are not recognized by TLR5. The driving force in the change of quaternary structure between Salmonella and Campylobacter may have been the evasion of TLR5. 10.1126/science.1155307 AU - Galkin, Vitold AU - Yu, Xiong AU - Bielnicki, Jakub AU - Heuser, John AU - Ewing, Cheryl AU - Guerry, Patricia AU - Egelman, Edward PY - 2008/04/18/ UR - http://dx.doi.org/10.1126/science.1155307 ER -