Serial Measurements of Cystatin C are More Accurate than Creatinine-based Methods in Detecting Declining Renal Function in Type 1 Diabetes.

@article{citeulike:2685953, abstract = {Objective Cystatin C and creatinine-based methods were compared with (99m)Tc-DTPA plasma clearance (isotopic Glomerular Filtration Rate or iGFR) for detecting declining renal function. Research Design and Methods: GFR was monitored over a mean of 10.1 years in 85 subjects with type 1 diabetes (average of 5.6 measurements per individual). Baseline mean iGFR of the cohort was 106.1+2.6ml/min/1.73m(2). The rates of decline in GFR (DeltaGFR) were derived using linear regression. Results In the 19/85 subjects with declining renal function (i.e. DeltaiGFR>3.3ml/min/1.73m(2) per year), DeltaGFR (ml/min/1.73m(2) per year) was: 6.5 by iGFR and 4.2 by 10(4)/creatinine, 3.6 by Cockcroft-Gault formula, 3.4 by MDRD-6 -equation and 3.5 by MDRD-4 variable-equation (p<0.01 versus iGFR). In comparison, DeltaGFR was 6.1 using the formula Cys-GFR=(86.7/cystatin C concentration)-4.2 (ns). Conclusions Cystatin C was more accurate in detecting decline in renal function than creatinine-based methods in this population of subjects with Type 1 and a normal mean baseline GFR.}, address = {Endocrine Centre/Austin Health, Medicine/University of Melbourne, Melbourne, Australia.}, author = {Premaratne, Erosha and Macisaac, Richard and Finch, Sue and Panagiotopoulos, Sianna and Ekinci, Elif and Jerums, George }, citeulike-article-id = {2685953}, doi = {http://dx.doi.org/10.2337/dc07-1588}, issn = {1935-5548}, journal = {Diabetes care}, month = {March}, posted-at = {2008-04-18 03:41:43}, priority = {2}, title = {Serial Measurements of Cystatin C are More Accurate than Creatinine-based Methods in Detecting Declining Renal Function in Type 1 Diabetes.}, url = {http://dx.doi.org/10.2337/dc07-1588}, year = {2008} }

TY - JOUR ID - citeulike:2685953 L3 - citeulike-article-id:2685953 TI - Serial Measurements of Cystatin C are More Accurate than Creatinine-based Methods in Detecting Declining Renal Function in Type 1 Diabetes. JF - Diabetes care AD - Endocrine Centre/Austin Health, Medicine/University of Melbourne, Melbourne, Australia. SN - 1935-5548 N2 - Objective Cystatin C and creatinine-based methods were compared with (99m)Tc-DTPA plasma clearance (isotopic Glomerular Filtration Rate or iGFR) for detecting declining renal function. Research Design and Methods: GFR was monitored over a mean of 10.1 years in 85 subjects with type 1 diabetes (average of 5.6 measurements per individual). Baseline mean iGFR of the cohort was 106.1+2.6ml/min/1.73m(2). The rates of decline in GFR (DeltaGFR) were derived using linear regression. Results In the 19/85 subjects with declining renal function (i.e. DeltaiGFR>3.3ml/min/1.73m(2) per year), DeltaGFR (ml/min/1.73m(2) per year) was: 6.5 by iGFR and 4.2 by 10(4)/creatinine, 3.6 by Cockcroft-Gault formula, 3.4 by MDRD-6 -equation and 3.5 by MDRD-4 variable-equation (p<0.01 versus iGFR). In comparison, DeltaGFR was 6.1 using the formula Cys-GFR=(86.7/cystatin C concentration)-4.2 (ns). Conclusions Cystatin C was more accurate in detecting decline in renal function than creatinine-based methods in this population of subjects with Type 1 and a normal mean baseline GFR. AU - Premaratne, Erosha AU - Macisaac, Richard AU - Finch, Sue AU - Panagiotopoulos, Sianna AU - Ekinci, Elif AU - Jerums, George PY - 2008/03/04/ UR - http://dx.doi.org/10.2337/dc07-1588 ER -