Enabling integrative genomic analysis of high-impact human diseases through text mining.

@article{citeulike:2799929, abstract = {Our limited ability to perform large-scale translational discovery and analysis of disease characterizations from public genomic data repositories remains a major bottleneck in efforts to translate genomics experiments to medicine. Through comprehensive, integrative genomic analysis of all available human disease characterizations we gain crucial insight into the molecular phenomena underlying pathogenesis as well as intra- and inter-disease differentiation. Such knowledge is crucial in the development of improved clinical diagnostics and the identification of molecular targets for novel therapeutics. In this study we build on our previous work to realize the next important step in large-scale translational discovery and analysis, which is to automatically identify those genomic experiments in which a disease state is compared to a normal control state. We present an automated text mining method that employs Natural Language Processing (NLP) techniques to automatically identify disease-related experiments in the NCBI Gene Expression Omnibus (GEO) that include measurements for both disease and normal control states. In this manner, we find that 62\% of disease-related experiments contain sample subsets that can be automatically identified as normal controls. Furthermore, we calculate that the identified experiments characterize diseases that contribute to 30\% of all human disease-related mortality in the United States. This work demonstrates that we now have the necessary tools and methods to initiate large-scale translational bioinformatics inquiry across the broad spectrum of high-impact human disease.}, address = {Stanford Medical Informatics, Departments of Medicine and Pediatrics, Stanford University School of Medicine, Stanford, CA 94305-5479, USA.}, author = {Dudley, J. and Butte, A. J. }, citeulike-article-id = {2799929}, issn = {1793-5091}, journal = {Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing}, keywords = {pubmed, text-mining}, pages = {580--591}, posted-at = {2008-05-16 13:54:44}, priority = {2}, title = {Enabling integrative genomic analysis of high-impact human diseases through text mining.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/18229717}, year = {2008} }

TY - JOUR ID - citeulike:2799929 L3 - citeulike-article-id:2799929 TI - Enabling integrative genomic analysis of high-impact human diseases through text mining. JF - Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing SP - 580 EP - 591 AD - Stanford Medical Informatics, Departments of Medicine and Pediatrics, Stanford University School of Medicine, Stanford, CA 94305-5479, USA. SN - 1793-5091 N2 - Our limited ability to perform large-scale translational discovery and analysis of disease characterizations from public genomic data repositories remains a major bottleneck in efforts to translate genomics experiments to medicine. Through comprehensive, integrative genomic analysis of all available human disease characterizations we gain crucial insight into the molecular phenomena underlying pathogenesis as well as intra- and inter-disease differentiation. Such knowledge is crucial in the development of improved clinical diagnostics and the identification of molecular targets for novel therapeutics. In this study we build on our previous work to realize the next important step in large-scale translational discovery and analysis, which is to automatically identify those genomic experiments in which a disease state is compared to a normal control state. We present an automated text mining method that employs Natural Language Processing (NLP) techniques to automatically identify disease-related experiments in the NCBI Gene Expression Omnibus (GEO) that include measurements for both disease and normal control states. In this manner, we find that 62% of disease-related experiments contain sample subsets that can be automatically identified as normal controls. Furthermore, we calculate that the identified experiments characterize diseases that contribute to 30% of all human disease-related mortality in the United States. This work demonstrates that we now have the necessary tools and methods to initiate large-scale translational bioinformatics inquiry across the broad spectrum of high-impact human disease. KW - pubmed KW - text-mining AU - Dudley, J AU - Butte, AJ PY - 2008/// UR - http://view.ncbi.nlm.nih.gov/pubmed/18229717 ER -