A genome-wide linkage analysis for the personality trait neuroticism in the Irish affected sib-pair study of alcohol dependence

@article{citeulike:1880146, abstract = {Neuroticism is a personality trait which reflects individual differences in emotional stability and vulnerability to stress and anxiety. Consistent evidence shows substantial genetic influences on variation in this trait. The present study seeks to identify regions containing susceptibility loci for neuroticism using a selected sib-pair sample from Ireland. Using Merlin regress, we conducted a 4 cM whole-genome linkage analysis on 714 sib-pairs. Evidence for linkage to neuroticism was found on chromosomes 11p, 12q, and 15q. The highest linkage peak was on 12q at marker D12S1638 with a Lod score of 2.13 (-log p = 2.76, empirical P-value \<0.001). Our data also support gender specific loci for neuroticism, with male specific linkage regions on chromosomes 1, 4, 11, 12, 15, 16, and 22, and female specific linkage regions on chromosomes 2, 4, 9, 12, 13, and 18. Some genome regions reported in the present study replicate findings from previous linkage studies of neuroticism. These results, together with prior studies, indicate several potential regions for quantitative trait loci for neuroticism that warrant further study. {\copyright} 2007 Wiley-Liss, Inc.}, address = {Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia; Shaftsbury Square Hospital, Belfast, Northern Ireland; Health Research Board, Dublin, Ireland; Department of Psychology, University of Southern California, Los Angeles, California}, author = {Kuo, Po-Hsiu and Neale, Michael C. and Riley, Brien P. and Patterson, Diana G. and Walsh, Dermot and Prescott, Carol A. and Kendler, Kenneth S. }, citeulike-article-id = {1880146}, doi = {http://dx.doi.org/10.1002/ajmg.b.30478}, journal = {American Journal of Medical Genetics Part B: Neuropsychiatric Genetics}, keywords = {genome-wide, neuroticism}, number = {4}, pages = {463--468}, posted-at = {2008-07-22 17:29:53}, priority = {2}, title = {A genome-wide linkage analysis for the personality trait neuroticism in the Irish affected sib-pair study of alcohol dependence}, url = {http://dx.doi.org/10.1002/ajmg.b.30478}, volume = {144B}, year = {2007} }

TY - JOUR ID - citeulike:1880146 L3 - citeulike-article-id:1880146 TI - A genome-wide linkage analysis for the personality trait neuroticism in the Irish affected sib-pair study of alcohol dependence JF - American Journal of Medical Genetics Part B: Neuropsychiatric Genetics VL - 144B IS - 4 SP - 463 EP - 468 AD - Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia; Shaftsbury Square Hospital, Belfast, Northern Ireland; Health Research Board, Dublin, Ireland; Department of Psychology, University of Southern California, Los Angeles, California N2 - Neuroticism is a personality trait which reflects individual differences in emotional stability and vulnerability to stress and anxiety. Consistent evidence shows substantial genetic influences on variation in this trait. The present study seeks to identify regions containing susceptibility loci for neuroticism using a selected sib-pair sample from Ireland. Using Merlin regress, we conducted a 4 cM whole-genome linkage analysis on 714 sib-pairs. Evidence for linkage to neuroticism was found on chromosomes 11p, 12q, and 15q. The highest linkage peak was on 12q at marker D12S1638 with a Lod score of 2.13 (-log p = 2.76, empirical P-value <0.001). Our data also support gender specific loci for neuroticism, with male specific linkage regions on chromosomes 1, 4, 11, 12, 15, 16, and 22, and female specific linkage regions on chromosomes 2, 4, 9, 12, 13, and 18. Some genome regions reported in the present study replicate findings from previous linkage studies of neuroticism. These results, together with prior studies, indicate several potential regions for quantitative trait loci for neuroticism that warrant further study. © 2007 Wiley-Liss, Inc. KW - genome-wide KW - neuroticism AU - Kuo, Po-Hsiu AU - Neale, Michael AU - Riley, Brien AU - Patterson, Diana AU - Walsh, Dermot AU - Prescott, Carol AU - Kendler, Kenneth PY - 2007/// UR - http://dx.doi.org/10.1002/ajmg.b.30478 ER -