Ovulation detection methods for urinary hormones: precision, daily and intermittent sampling and a combined hierarchical method

@article{citeulike:2327104, abstract = {BACKGROUND: We evaluate the performance of ovulation detection methods and present new approaches, including evaluation of methods for precision, combining multiple markers into a hierarchical system and using ovulation markers in intermittent sampling designs. METHODS: With serum LH peak day as the gold standard' of ovulation, we estimated accuracy and precision of ovulation day algorithms using 30 ovulatory menstrual cycles with daily urinary and serum hormones and transvaginal ultrasound. Sensitivity and specificity for estimating the presence of ovulation were tested using visually assessed ovulatory (30) and anovulatory (22) cycles. RESULTS: Sensitivity and specificity ranged from 70 to 100\% for estimating presence of ovulation with twice-per-cycle, weekly, twice weekly, every-other-day and daily specimens. A combined hierarchical method estimated ovulation day using daily specimens within {+/-}2 days of the gold standard in 93\% of cases. Accuracy of estimating ovulation day within {+/-}2 days using intermittent sampling ranged from 40\% (weekly sampling) to 97\% (every-other-day). CONCLUSIONS: A combined hierarchical algorithm using precise and accurate markers allows maximal use of available data for efficient and objective identification of ovulation using daily specimens. In intermittent sampling designs, the presence and the timing of ovulation can be estimated with good sensitivity, specificity and accuracy. 10.1093/humrep/dei497}, author = {O'Connor, K. A. and Brindle, E. and Miller, R. C. and Shofer, J. B. and Ferrell, R. J. and Klein, N. A. and Soules, M. R. and Holman, D. J. and Mansfield, P. K. and Wood, J. W. }, citeulike-article-id = {2327104}, doi = {10.1093/humrep/dei497}, journal = {Hum. Reprod.}, keywords = {fsh, lh, ovulation, urinaryhormones}, month = {June}, number = {6}, pages = {1442--1452}, posted-at = {2008-02-03 20:09:25}, priority = {3}, title = {Ovulation detection methods for urinary hormones: precision, daily and intermittent sampling and a combined hierarchical method}, url = {http://dx.doi.org/10.1093/humrep/dei497}, volume = {21}, year = {2006} }

TY - JOUR ID - citeulike:2327104 L3 - citeulike-article-id:2327104 TI - Ovulation detection methods for urinary hormones: precision, daily and intermittent sampling and a combined hierarchical method JF - Hum. Reprod. VL - 21 IS - 6 SP - 1442 EP - 1452 N2 - BACKGROUND: We evaluate the performance of ovulation detection methods and present new approaches, including evaluation of methods for precision, combining multiple markers into a hierarchical system and using ovulation markers in intermittent sampling designs. METHODS: With serum LH peak day as the gold standard' of ovulation, we estimated accuracy and precision of ovulation day algorithms using 30 ovulatory menstrual cycles with daily urinary and serum hormones and transvaginal ultrasound. Sensitivity and specificity for estimating the presence of ovulation were tested using visually assessed ovulatory (30) and anovulatory (22) cycles. RESULTS: Sensitivity and specificity ranged from 70 to 100% for estimating presence of ovulation with twice-per-cycle, weekly, twice weekly, every-other-day and daily specimens. A combined hierarchical method estimated ovulation day using daily specimens within {+/-}2 days of the gold standard in 93% of cases. Accuracy of estimating ovulation day within {+/-}2 days using intermittent sampling ranged from 40% (weekly sampling) to 97% (every-other-day). CONCLUSIONS: A combined hierarchical algorithm using precise and accurate markers allows maximal use of available data for efficient and objective identification of ovulation using daily specimens. In intermittent sampling designs, the presence and the timing of ovulation can be estimated with good sensitivity, specificity and accuracy. 10.1093/humrep/dei497 KW - fsh KW - lh KW - ovulation KW - urinaryhormones AU - O'Connor, KA AU - Brindle, E AU - Miller, RC AU - Shofer, JB AU - Ferrell, RJ AU - Klein, NA AU - Soules, MR AU - Holman, DJ AU - Mansfield, PK AU - Wood, JW PY - 2006/06/01/ UR - http://dx.doi.org/10.1093/humrep/dei497 ER -