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ndoelkers ccr5 [17 articles]

Artikler nylig sendt til ndoelkers bibliotek klassifisert med nøkkelordet ccr5. You can also see everyone's ccr5.
  • Characterization of the role of the N-loop of MIP-1 beta in CCR5 binding.
    Biochemistry, Vol. 41, No. 46. (19 November 2002), pp. 13548-13555.
    by A Bondue, SC Jao, C Blanpain, M Parmentier, PJ LiWang
    posted to chemokine ccr5 binding by ndoelker on 2007-01-20 15:08:17 as *** along with 1 group LabCompMed
  • Constitutive activation of CCR5 and CCR2 induced by conformational changes in the conserved TXP motif in transmembrane helix 2.
    J Biol Chem, Vol. 278, No. 38. (Sep 2003), pp. 36513-36521.
    by Diana A Arias, Jean M Navenot, Wen B Zhang, James Broach, Stephen C Peiper
  • A small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activity.
    Proc Natl Acad Sci U S A, Vol. 96, No. 10. (May 1999), pp. 5698-703.
  • The core domain of chemokines binds CCR5 extracellular domains while their amino terminus interacts with the transmembrane helix bundle.
    J Biol Chem, Vol. 278, No. 7. (Feb 2003), pp. 5179-87.
    by Cã©dric Blanpain, Benjamin J Doranz, Antoine Bondue, Cã©dric Govaerts, Anne De Leener, Gilbert Vassart, Robert W Doms, Amanda Proudfoot, Marc Parmentier
  • Generation of predictive pharmacophore models for CCR5 antagonists: study with piperidine- and piperazine-based compounds as a new class of HIV-1 entry inhibitors.
    J Med Chem, Vol. 46, No. 21. (Oct 2003), pp. 4501-15.
    by Asim K Debnath
  • A binding pocket for a small molecule inhibitor of HIV-1 entry within the transmembrane helices of CCR5.
    Proc Natl Acad Sci U S A, Vol. 97, No. 10. (May 2000), pp. 5639-44.
    by T Dragic, A Trkola, DA Thompson, EG Cormier, FA Kajumo, E Maxwell, SW Lin, W Ying, SO Smith, TP Sakmar, JP Moore
  • The TXP motif in the second transmembrane helix of CCR5. A structural determinant of chemokine-induced activation.
    J Biol Chem, Vol. 276, No. 16. (Apr 2001), pp. 13217-13225.
  • Activation of CCR5 by chemokines involves an aromatic cluster between transmembrane helices 2 and 3.
    J Biol Chem, Vol. 278, No. 3. (Jan 2003), pp. 1892-903.
    by Cã©dric Govaerts, Antoine Bondue, Jean Y Springael, Mireia Olivella, Xavier Deupi, Emmanuel Le Poul, Shoshana J Wodak, Marc Parmentier, Leonardo Pardo, Cã©dric Blanpain
  • A small molecule HIV-1 inhibitor that targets the HIV-1 envelope and inhibits CD4 receptor binding.
    Proc Natl Acad Sci U S A, Vol. 100, No. 19. (Sep 2003), pp. 11013-8.
    by Pin F Lin, Wade Blair, Tao Wang, Timothy Spicer, Qi Guo, Nannan Zhou, Yi F Gong, Heidi HG Wang, Ronald Rose, Gregory Yamanaka, Brett Robinson, Chang B Li, Robert Fridell, Carol Deminie, Gwendeline Demers, Zheng Yang, Lisa Zadjura, Nicholas Meanwell, Ard Colonno
    posted to bibtex-nicole binding ccr5 cxcr4 by ndoelker on 2006-10-30 16:53:00 as read along with 1 group LabCompMed
  • Five-transmembrane domains appear sufficient for a G protein-coupled receptor: functional five-transmembrane domain chemokine receptors.
    Proc Natl Acad Sci U S A, Vol. 96, No. 14. (Jul 1999), pp. 7922-7927.
    by K Ling, P Wang, J Zhao, YL Wu, ZJ Cheng, GX Wu, W Hu, L Ma, G Pei
  • Novel low molecular weight spirodiketopiperazine derivatives potently inhibit R5 HIV-1 infection through their antagonistic effects on CCR5.
    J Biol Chem, Vol. 276, No. 37. (Sep 2001), pp. 35194-200.
  • Molecular anatomy of CCR5 engagement by physiologic and viral chemokines and HIV-1 envelope glycoproteins: differences in primary structural requirements for RANTES, MIP-1 alpha, and vMIP-II Binding.
    J Mol Biol, Vol. 313, No. 5. (Nov 2001), pp. 1181-93.
    by JM Navenot, ZX Wang, JO Trent, JL Murray, QX Hu, L Deleeuw, PS Moore, Y Chang, SC Peiper
  • Structure modeling of the chemokine receptor CCR5: implications for ligand binding and selectivity.
    Biophys J, Vol. 83, No. 6. (Dec 2002), pp. 3012-31.
    by Germana M Paterlini
  • SCH-C (SCH 351125), an orally bioavailable, small molecule antagonist of the chemokine receptor CCR5, is a potent inhibitor of HIV-1 infection in vitro and in vivo.
    Proc Natl Acad Sci U S A, Vol. 98, No. 22. (Oct 2001), pp. 12718-23.
    by JM Strizki, S Xu, NE Wagner, L Wojcik, J Liu, Y Hou, M Endres, A Palani, S Shapiro, JW Clader, WJ Greenlee, JR Tagat, S Mccombie, K Cox, AB Fawzi, CC Chou, Pugliese C Sivo, L Davies, ME Moreno, DD Ho, A Trkola, CA Stoddart, JP Moore, GR Reyes, BM Baroudy
  • Piperazine-based CCR5 antagonists as HIV-1 inhibitors. IV. Discovery of 1-[(4,6-dimethyl-5-pyrimidinyl)carbonyl]- 4-[4-[2-methoxy-1(R)-4-(trifluoromethyl)phenyl]ethyl-3(S)-methyl-1-piperazinyl]- 4-methylpiperidine (Sch-417690/Sch-D), a potent, highly selective, and orally bioavailable CCR5 antagonist.
    J Med Chem, Vol. 47, No. 10. (May 2004), pp. 2405-8.
    by Jayaram R Tagat, Stuart W Mccombie, Dennis Nazareno, Marc A Labroli, Yushi Xiao, Ruo W Steensma, Julie M Strizki, Bahige M Baroudy, Kathleen Cox, Jean Lachowicz, Geoffrey Varty, Robert Watkins
  • Molecular docking and 3D QSAR studies on 1-amino-2-phenyl-4-(piperidin-1-yl)-butanes based on the structural modeling of human CCR5 receptor.
    Bioorg Med Chem, Vol. 12, No. 23. (Dec 2004), pp. 6193-208.
    by Yong Xu, Hong Liu, Chunying Niu, Cheng Luo, Xiaomin Luo, Jianhua Shen, Kaixian Chen, Hualiang Jiang
  • Molecular modeling and site-directed mutagenesis of CCR5 reveal residues critical for chemokine binding and signal transduction.
    Eur J Immunol, Vol. 30, No. 1. (Jan 2000), pp. 164-73.
    by N Zhou, Z Luo, JW Hall, J Luo, X Han, Z Huang
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