AMYPdb: a database dedicated to amyloid precursor proteins

@article{citeulike:2879329, abstract = {BACKGROUND:Misfolding and aggregation of proteins into ordered fibrillar structures is associated with a number of severe pathologies, including Alzheimer's disease, prion diseases, and type II diabetes. The rapid accumulation of knowledge about the sequences and structures of these proteins allows using of in silico methods to investigate the molecular mechanisms of their abnormal conformational changes and assembly. However, such an approach requires the collection of accurate data, which are inconveniently dispersed among several generalist databases.RESULTS:We therefore created a free online knowledge database (AMYPdb) dedicated to amyloid precursor proteins and we have performed large scale sequence analysis of the included data. Currently, AMYPdb integrates data on 31 families, including 1,705 proteins from nearly 600 organisms. It displays links to more than 2,300 bibliographic references and 1,200 3D-structures. A Wiki system is available to insert data into the database, providing a sharing and collaboration environment. We generated and analyzed 3,621 amino acid sequence patterns, reporting highly specific patterns for each amyloid family, along with patterns likely to be involved in protein misfolding and aggregation.CONCLUSIONS:AMYPdb is a comprehensive online database aiming at the centralization of bioinformatic data regarding all amyloid proteins and their precursors. Our sequence pattern discovery and analysis approach unveiled protein regions of significant interest. AMYPdb is freely accessible at http://amypdb.univ-rennes1.fr.}, author = {Pawlicki, Sandrine and Le Bechec, Antony and Delamarche, Christian }, citeulike-article-id = {2879329}, doi = {10.1186/1471-2105-9-273}, journal = {BMC Bioinformatics}, keywords = {amyloid, database, folding, protein, webserver}, number = {1}, posted-at = {2008-06-10 12:58:59}, priority = {2}, title = {AMYPdb: a database dedicated to amyloid precursor proteins}, url = {http://dx.doi.org/10.1186/1471-2105-9-273}, volume = {9}, year = {2008} }

TY - JOUR ID - citeulike:2879329 L3 - citeulike-article-id:2879329 TI - AMYPdb: a database dedicated to amyloid precursor proteins JF - BMC Bioinformatics VL - 9 IS - 1 N2 - BACKGROUND:Misfolding and aggregation of proteins into ordered fibrillar structures is associated with a number of severe pathologies, including Alzheimer's disease, prion diseases, and type II diabetes. The rapid accumulation of knowledge about the sequences and structures of these proteins allows using of in silico methods to investigate the molecular mechanisms of their abnormal conformational changes and assembly. However, such an approach requires the collection of accurate data, which are inconveniently dispersed among several generalist databases.RESULTS:We therefore created a free online knowledge database (AMYPdb) dedicated to amyloid precursor proteins and we have performed large scale sequence analysis of the included data. Currently, AMYPdb integrates data on 31 families, including 1,705 proteins from nearly 600 organisms. It displays links to more than 2,300 bibliographic references and 1,200 3D-structures. A Wiki system is available to insert data into the database, providing a sharing and collaboration environment. We generated and analyzed 3,621 amino acid sequence patterns, reporting highly specific patterns for each amyloid family, along with patterns likely to be involved in protein misfolding and aggregation.CONCLUSIONS:AMYPdb is a comprehensive online database aiming at the centralization of bioinformatic data regarding all amyloid proteins and their precursors. Our sequence pattern discovery and analysis approach unveiled protein regions of significant interest. AMYPdb is freely accessible at http://amypdb.univ-rennes1.fr. KW - amyloid KW - database KW - folding KW - protein KW - webserver AU - Pawlicki, Sandrine AU - Le Bechec, Antony AU - Delamarche, Christian PY - 2008/// UR - http://dx.doi.org/10.1186/1471-2105-9-273 ER -