Hippocampal place cells acquire location-specific responses to the conditioned stimulus during auditory fear conditioning.

@article{citeulike:2901921, abstract = {We recorded neurons from the hippocampus of freely behaving rats during an auditory fear conditioning task. Rats received either paired or unpaired presentations of an auditory conditioned stimulus (CS) and an electric shock unconditioned stimulus (US). Hippocampal neurons (place and theta cells) acquired responses to the auditory CS in the paired but not in the unpaired group. After CS-US pairing, rhythmic firing of theta cells became synchronized to the onset of the CS. Conditioned responses of place cells were gated by their location-specific firing, so that after CS-US pairing, place cells responded to the CS only when the rat was within the cell's place field. These findings may help to elucidate how the hippocampus contributes to context-specific memory formation during associative learning.}, address = {Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA. blair@psych.ucla.edu}, author = {Moita, M. A. and Rosis, S. and Zhou, Y. and LeDoux, J. E. and Blair, H. T. }, citeulike-article-id = {2901921}, issn = {0896-6273}, journal = {Neuron}, keywords = {auditory, fear-conditioning, hippocampus, place-cell, rats}, month = {February}, number = {3}, pages = {485--497}, posted-at = {2008-06-17 11:02:00}, priority = {2}, title = {Hippocampal place cells acquire location-specific responses to the conditioned stimulus during auditory fear conditioning.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/12575955}, volume = {37}, year = {2003} }

TY - JOUR ID - citeulike:2901921 L3 - citeulike-article-id:2901921 TI - Hippocampal place cells acquire location-specific responses to the conditioned stimulus during auditory fear conditioning. JF - Neuron VL - 37 IS - 3 SP - 485 EP - 497 AD - Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA. blair@psych.ucla.edu SN - 0896-6273 N2 - We recorded neurons from the hippocampus of freely behaving rats during an auditory fear conditioning task. Rats received either paired or unpaired presentations of an auditory conditioned stimulus (CS) and an electric shock unconditioned stimulus (US). Hippocampal neurons (place and theta cells) acquired responses to the auditory CS in the paired but not in the unpaired group. After CS-US pairing, rhythmic firing of theta cells became synchronized to the onset of the CS. Conditioned responses of place cells were gated by their location-specific firing, so that after CS-US pairing, place cells responded to the CS only when the rat was within the cell's place field. These findings may help to elucidate how the hippocampus contributes to context-specific memory formation during associative learning. KW - auditory KW - fear-conditioning KW - hippocampus KW - place-cell KW - rats AU - Moita, MA AU - Rosis, S AU - Zhou, Y AU - LeDoux, JE AU - Blair, HT PY - 2003/02/06/ UR - http://view.ncbi.nlm.nih.gov/pubmed/12575955 ER -