Pharmacokinetics and pharmacodynamics of rocuronium bromide in adult patients.

by: JA Alvarez-Gomez, ME Estelles, J Fabregat, F Perez, AJ Brugger

European journal of anaesthesiology. Supplement, Vol. 9 (1994), pp. 53-56.

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Abstract

In seven patients (M/F: 4:3) rocuronium 0.6 mg kg-1 was given after the induction of anaesthesia with propofol, and during maintenance with N2O/O2, halothane 0.5% and alfentanil 60-90 micrograms kg-1 h-1. Intubation conditions were scored at 60 s and lag time, onset time, maximal block achieved, recovery to 25% of T1, and Recovery Index, were measured using a Relaxograph. Blood samples were taken over a 300 min period and analysed for rocuronium. Intubating conditions at 60 s were excellent in all patients. Mean clearance was 5.2 ml kg-1 min-1, the terminal half-life was 69 min and distribution volume at steady state was 0.22 litre kg-1. Cumulative urinary excretion was around 18% within 24 h.

@article{citeulike:2894541, abstract = {In seven patients (M/F: 4:3) rocuronium 0.6 mg kg-1 was given after the induction of anaesthesia with propofol, and during maintenance with N2O/O2, halothane 0.5\% and alfentanil 60-90 micrograms kg-1 h-1. Intubation conditions were scored at 60 s and lag time, onset time, maximal block achieved, recovery to 25\% of T1, and Recovery Index, were measured using a Relaxograph. Blood samples were taken over a 300 min period and analysed for rocuronium. Intubating conditions at 60 s were excellent in all patients. Mean clearance was 5.2 ml kg-1 min-1, the terminal half-life was 69 min and distribution volume at steady state was 0.22 litre kg-1. Cumulative urinary excretion was around 18\% within 24 h.}, address = {Santa Maria del Rosell Hospital, Cartagena, Spain.}, author = {Alvarez-Gomez, J. A. and Estelles, M. E. and Fabregat, J. and Perez, F. and Brugger, A. J. }, citeulike-article-id = {2894541}, issn = {0952-1941}, journal = {European journal of anaesthesiology. Supplement}, keywords = {and, of, ph, roc}, pages = {53--56}, posted-at = {2008-06-14 12:21:35}, priority = {2}, title = {Pharmacokinetics and pharmacodynamics of rocuronium bromide in adult patients.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/7925209}, volume = {9}, year = {1994} }

RIS record

TY - JOUR ID - citeulike:2894541 L3 - citeulike-article-id:2894541 TI - Pharmacokinetics and pharmacodynamics of rocuronium bromide in adult patients. JF - European journal of anaesthesiology. Supplement VL - 9 SP - 53 EP - 56 AD - Santa Maria del Rosell Hospital, Cartagena, Spain. SN - 0952-1941 N2 - In seven patients (M/F: 4:3) rocuronium 0.6 mg kg-1 was given after the induction of anaesthesia with propofol, and during maintenance with N2O/O2, halothane 0.5% and alfentanil 60-90 micrograms kg-1 h-1. Intubation conditions were scored at 60 s and lag time, onset time, maximal block achieved, recovery to 25% of T1, and Recovery Index, were measured using a Relaxograph. Blood samples were taken over a 300 min period and analysed for rocuronium. Intubating conditions at 60 s were excellent in all patients. Mean clearance was 5.2 ml kg-1 min-1, the terminal half-life was 69 min and distribution volume at steady state was 0.22 litre kg-1. Cumulative urinary excretion was around 18% within 24 h. KW - and KW - of KW - ph KW - roc AU - Alvarez-Gomez, JA AU - Estelles, ME AU - Fabregat, J AU - Perez, F AU - Brugger, AJ PY - 1994/// UR - http://view.ncbi.nlm.nih.gov/pubmed/7925209 ER -

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