Long-Term Modulation of Electrical Synapses in the Mammalian Thalamus

by: Carole E Landisman, Barry W Connors

Science, Vol. 310, No. 5755. (16 December 2005), pp. 1809-1813.

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Abstract

Electrical synapses are common between inhibitory neurons in the mammalian thalamus and neocortex. Synaptic modulation, which allows flexibility of communication between neurons, has been studied extensively at chemical synapses, but modulation of electrical synapses in the mammalian brain has barely been examined. We found that the activation of metabotropic glutamate receptors, via endogenous neurotransmitter or by agonist, causes long-term reduction of electrical synapse strength between the inhibitory neurons of the rat thalamic reticular nucleus.

@article{citeulike:439266, abstract = {Electrical synapses are common between inhibitory neurons in the mammalian thalamus and neocortex. Synaptic modulation, which allows flexibility of communication between neurons, has been studied extensively at chemical synapses, but modulation of electrical synapses in the mammalian brain has barely been examined. We found that the activation of metabotropic glutamate receptors, via endogenous neurotransmitter or by agonist, causes long-term reduction of electrical synapse strength between the inhibitory neurons of the rat thalamic reticular nucleus.}, author = {Landisman, Carole E. and Connors, Barry W. }, citeulike-article-id = {439266}, doi = {http://dx.doi.org/10.1126/science.1114655}, journal = {Science}, keywords = {gap-jonction, plasticity, thalamus}, month = {December}, number = {5755}, pages = {1809--1813}, posted-at = {2008-06-02 16:14:20}, priority = {2}, title = {Long-Term Modulation of Electrical Synapses in the Mammalian Thalamus}, url = {http://dx.doi.org/10.1126/science.1114655}, volume = {310}, year = {2005} }

RIS record

TY - JOUR ID - citeulike:439266 L3 - citeulike-article-id:439266 TI - Long-Term Modulation of Electrical Synapses in the Mammalian Thalamus JF - Science VL - 310 IS - 5755 SP - 1809 EP - 1813 N2 - Electrical synapses are common between inhibitory neurons in the mammalian thalamus and neocortex. Synaptic modulation, which allows flexibility of communication between neurons, has been studied extensively at chemical synapses, but modulation of electrical synapses in the mammalian brain has barely been examined. We found that the activation of metabotropic glutamate receptors, via endogenous neurotransmitter or by agonist, causes long-term reduction of electrical synapse strength between the inhibitory neurons of the rat thalamic reticular nucleus. KW - gap-jonction KW - plasticity KW - thalamus AU - Landisman, Carole AU - Connors, Barry PY - 2005/12/16/ UR - http://dx.doi.org/10.1126/science.1114655 ER -

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