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Iridium-complex-functionalized Fe3O4/SiO2 core/shell nanoparticles: a facile three-in-one system in magnetic resonance imaging, luminescence imaging, and photodynamic therapy.

by: CW Lai, YH Wang, CH Lai, MJ Yang, CY Chen, PT Chou, CS Chan, Y Chi, YC Chen, JK Hsiao
Small (Weinheim an der Bergstrasse, Germany), Vol. 4, No. 2. (February 2008), pp. 218-224.


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Highly uniform Fe3O4/SiO2 core/shell nanoparticles functionalized by phosphorescent iridium complexes (Ir) have been strategically designed and synthesized. The Fe3O4/SiO2(Ir) nanocomposite demonstrates its versatility in various applications: the magnetic core provides the capability for magnetic resonance imaging and the great enhancement of the spin-orbit coupling in the iridium complex makes it well suited for phosphorescent labeling and simultaneous singlet oxygen generation to induce apoptosis.


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