Encapsulation of methylene blue in polyacrylamide nanoparticle platforms protects its photodynamic effectiveness

by: Wei Tang, Hao Xu, Edwin J Park, Martin A Philbert, Raoul Kopelman

Biochemical and Biophysical Research Communications, Vol. 369, No. 2. (2 May 2008), pp. 579-583.

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Abstract

The ability to prevent methylene blue (MB), a photosensitizer, from being reduced by plasma reductases will greatly improve its efficacy in photodynamic therapy (PDT) applications. We have developed a delivery approach for PDT by encapsulating MB using nanoparticle platforms (NPs). The 30-nm polyacrylamide-based NPs provide protection for the embedded MB against reduction by diaphorase enzymes. Furthermore, our data shows the matrix-protected MB efficiently induces photodynamic damage to tumor cells. The unprecedented results demonstrate the significant in vitro photodynamic effectiveness of MB when encapsulated within NPs, which promises to open new opportunities for MB in its in vivo and clinical studies.

@article{citeulike:2793338, abstract = {The ability to prevent methylene blue (MB), a photosensitizer, from being reduced by plasma reductases will greatly improve its efficacy in photodynamic therapy (PDT) applications. We have developed a delivery approach for PDT by encapsulating MB using nanoparticle platforms (NPs). The 30-nm polyacrylamide-based NPs provide protection for the embedded MB against reduction by diaphorase enzymes. Furthermore, our data shows the matrix-protected MB efficiently induces photodynamic damage to tumor cells. The unprecedented results demonstrate the significant in vitro photodynamic effectiveness of MB when encapsulated within NPs, which promises to open new opportunities for MB in its in vivo and clinical studies.}, author = {Tang, Wei and Xu, Hao and Park, Edwin J. and Philbert, Martin A. and Kopelman, Raoul }, citeulike-article-id = {2793338}, doi = {10.1016/j.bbrc.2008.02.066}, journal = {Biochemical and Biophysical Research Communications}, keywords = {blue, citedby, encapsulation, methylene, nanoparticles, pdt, photodynamic, polyacrylamide, therapy}, month = {May}, number = {2}, pages = {579--583}, posted-at = {2008-05-13 05:04:47}, priority = {2}, title = {Encapsulation of methylene blue in polyacrylamide nanoparticle platforms protects its photodynamic effectiveness}, url = {http://dx.doi.org/10.1016/j.bbrc.2008.02.066}, volume = {369}, year = {2008} }

RIS record

TY - JOUR ID - citeulike:2793338 L3 - citeulike-article-id:2793338 TI - Encapsulation of methylene blue in polyacrylamide nanoparticle platforms protects its photodynamic effectiveness JF - Biochemical and Biophysical Research Communications VL - 369 IS - 2 SP - 579 EP - 583 N2 - The ability to prevent methylene blue (MB), a photosensitizer, from being reduced by plasma reductases will greatly improve its efficacy in photodynamic therapy (PDT) applications. We have developed a delivery approach for PDT by encapsulating MB using nanoparticle platforms (NPs). The 30-nm polyacrylamide-based NPs provide protection for the embedded MB against reduction by diaphorase enzymes. Furthermore, our data shows the matrix-protected MB efficiently induces photodynamic damage to tumor cells. The unprecedented results demonstrate the significant in vitro photodynamic effectiveness of MB when encapsulated within NPs, which promises to open new opportunities for MB in its in vivo and clinical studies. KW - blue KW - citedby KW - encapsulation KW - methylene KW - nanoparticles KW - pdt KW - photodynamic KW - polyacrylamide KW - therapy AU - Tang, Wei AU - Xu, Hao AU - Park, Edwin AU - Philbert, Martin AU - Kopelman, Raoul PY - 2008/05/02/ UR - http://dx.doi.org/10.1016/j.bbrc.2008.02.066 ER -

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