The product of the tobacco mosaic virus resistance gene N: similarity to toll and the interleukin-1 receptor.

@article{citeulike:1186465, abstract = {The products of plant disease resistance genes are postulated to recognize invading pathogens and rapidly trigger host defense responses. Here we describe isolation of the resistance gene N of tobacco that mediates resistance to the viral pathogen tobacco mosaic virus (TMV). The N gene was isolated by transposon tagging using the maize Activator transposon. A genomic DNA fragment containing the N gene conferred TMV resistance to TMV susceptible tobacco. Sequence analysis of the N gene shows that it encodes a protein of 131.4 kDa with an amino-terminal domain similar to that of the cytoplasmic domain of the Drosophila Toll protein and the interleukin-1 receptor (IL-1R) in mammals, a nucleotide-binding site (NBS), and 14 [corrected] imperfect leucine-rich repeats (LRR). The sequence similarity of N, Toll, and IL-1R suggests that N mediates rapid gene induction and TMV resistance through a Toll-IL-1-like pathway.}, address = {Department of Plant Pathology, University of California, Berkeley 94720.}, author = {Whitham, S. and Dinesh-Kumar, S. P. and Choi, D. and Hehl, R. and Corr, C. and Baker, B. }, citeulike-article-id = {1186465}, issn = {0092-8674}, journal = {Cell}, keywords = {n, r}, month = {September}, number = {6}, pages = {1101--1115}, posted-at = {2007-03-26 04:20:40}, priority = {2}, title = {The product of the tobacco mosaic virus resistance gene N: similarity to toll and the interleukin-1 receptor.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/7923359}, volume = {78}, year = {1994} }

TY - JOUR ID - citeulike:1186465 L3 - citeulike-article-id:1186465 TI - The product of the tobacco mosaic virus resistance gene N: similarity to toll and the interleukin-1 receptor. JF - Cell VL - 78 IS - 6 SP - 1101 EP - 1115 AD - Department of Plant Pathology, University of California, Berkeley 94720. SN - 0092-8674 N2 - The products of plant disease resistance genes are postulated to recognize invading pathogens and rapidly trigger host defense responses. Here we describe isolation of the resistance gene N of tobacco that mediates resistance to the viral pathogen tobacco mosaic virus (TMV). The N gene was isolated by transposon tagging using the maize Activator transposon. A genomic DNA fragment containing the N gene conferred TMV resistance to TMV susceptible tobacco. Sequence analysis of the N gene shows that it encodes a protein of 131.4 kDa with an amino-terminal domain similar to that of the cytoplasmic domain of the Drosophila Toll protein and the interleukin-1 receptor (IL-1R) in mammals, a nucleotide-binding site (NBS), and 14 [corrected] imperfect leucine-rich repeats (LRR). The sequence similarity of N, Toll, and IL-1R suggests that N mediates rapid gene induction and TMV resistance through a Toll-IL-1-like pathway. KW - n KW - r AU - Whitham, S AU - Dinesh-Kumar, SP AU - Choi, D AU - Hehl, R AU - Corr, C AU - Baker, B PY - 1994/09/23/ UR - http://view.ncbi.nlm.nih.gov/pubmed/7923359 ER -