Methyl-CpG-binding domain (MBD) proteins in plants

@article{citeulike:2322243, abstract = {Cytosine methylation is the most prevalent epigenetic modification of plant nuclear DNA, which occurs in symmetrical CpG or CpNpG as well as in non-symmetrical contexts. Intensive studies demonstrated the central role played by cytosine methylation in genome organization, gene expression and in plant growth and development. However, the way by which the methyl group is interpreted into a functional state has only recently begun to be explored with the isolation and characterization of methylated DNA binding proteins capable of binding 5-methylcytosine. These proteins belong to an evolutionary conserved protein family initially described in animals termed methyl-CpG-binding domain (MBD) proteins. Here, we highlight recent advances and present new prospects concerning plant MBD proteins and their possible role in controlling chromatin structure mediated by CpG methylation.}, author = {Grafi, Gideon and Zemach, Assaf and Pitto, Letizia }, booktitle = {Plant Chromatin: Structure and Expression}, citeulike-article-id = {2322243}, doi = {10.1016/j.bbaexp.2007.02.004}, journal = {Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression}, keywords = {methylation, review}, month = {}, number = {5-6}, pages = {287--294}, posted-at = {2008-02-02 05:45:51}, priority = {2}, title = {Methyl-CpG-binding domain (MBD) proteins in plants}, url = {http://dx.doi.org/10.1016/j.bbaexp.2007.02.004}, volume = {1769}, year = {2007} }

TY - JOUR ID - citeulike:2322243 L3 - citeulike-article-id:2322243 TI - Methyl-CpG-binding domain (MBD) proteins in plants T2 - Plant Chromatin: Structure and Expression JF - Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression VL - 1769 IS - 5-6 SP - 287 EP - 294 N2 - Cytosine methylation is the most prevalent epigenetic modification of plant nuclear DNA, which occurs in symmetrical CpG or CpNpG as well as in non-symmetrical contexts. Intensive studies demonstrated the central role played by cytosine methylation in genome organization, gene expression and in plant growth and development. However, the way by which the methyl group is interpreted into a functional state has only recently begun to be explored with the isolation and characterization of methylated DNA binding proteins capable of binding 5-methylcytosine. These proteins belong to an evolutionary conserved protein family initially described in animals termed methyl-CpG-binding domain (MBD) proteins. Here, we highlight recent advances and present new prospects concerning plant MBD proteins and their possible role in controlling chromatin structure mediated by CpG methylation. KW - methylation KW - review AU - Grafi, Gideon AU - Zemach, Assaf AU - Pitto, Letizia PY - 2007/0// UR - http://dx.doi.org/10.1016/j.bbaexp.2007.02.004 ER -