Assessment of renal hemodynamics and function in pigs with 64-section multidetector CT: Comparison with electron-beam CT

@article{citeulike:1648016, abstract = {Purpose: To prospectively evaluate the feasibility of obtaining reliable measurements of renal hemodynamics and function by using 64-section multideteetor CT. Materials and Methods: This study was approved by the Institutional Animal Care and Use Committee. Eight pigs (two with induced unilateral renal artery stenosis) were studied with both electron-beam CT and 64-section multidetector CT at 1-week intervals in randomized order. Both kidneys were scanned repeatedly, without table movement, for about 3 minutes alter intravenous (IV) administration of a bolus of contrast medium and again during vasodilator challenge (acetylcholine). Images were reconstructed on each CT console but were analyzed on the same independent workstation. Attenuation changes in the kidneys were plotted as function of time, and time-attenuation curves (TACs) were subsequently analyzed to determine regional perfusion and volume, glomerular filtration rate (CFR), and renal blood flow (RBF). Statistical analysis utilized Student t test, analysis of variance (ANOVA), linear regression, and Bland-Alt-man analysis. Results: TACs obtained with multidetector CT were qualitatively similar to those obtained with electron-beam CT, as were the quantitative values of renal perfusion and function. RBF correlated significantly between the two techniques (RBFMD = 0.96·RBFEB mL/min; R = 0.77, P < .0). GFBMD was also similar to GFREB (77.6 ± 8.3 vs 79.8 ± 8.8 mL/min, p > .05). Bland-Altman plots showed good agreement between the two techniques. Both techniques similarly detected the differences between stenotic and contralateral kidneys. Conclusion: The clinical multidetector CT scanner provides reliable measurements of single-kidney hemodynamics and function, which are similar to those obtained with previously validated electron-beam CT. {\copyright} RSNA, 2007.}, address = {Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, United States}, author = {Daghini, E. and Primak, A. N. and Chade, A. R. and Krier, J. D. and Zhu, X. Y. and Ritman, E. L. and Mccollough, C. H. and Lerman, L. O. }, citeulike-article-id = {1648016}, doi = {http://dx.doi.org/10.1148/radiol.2432060655}, journal = {Radiology}, keywords = {beam, comparison, ct, electro, multidetector}, number = {2}, pages = {405--412}, posted-at = {2007-09-12 14:34:07}, priority = {2}, title = {Assessment of renal hemodynamics and function in pigs with 64-section multidetector CT: Comparison with electron-beam CT}, url = {http://dx.doi.org/10.1148/radiol.2432060655}, volume = {243}, year = {2007} }

TY - JOUR ID - citeulike:1648016 L3 - citeulike-article-id:1648016 TI - Assessment of renal hemodynamics and function in pigs with 64-section multidetector CT: Comparison with electron-beam CT JF - Radiology VL - 243 IS - 2 SP - 405 EP - 412 AD - Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, United States N2 - Purpose: To prospectively evaluate the feasibility of obtaining reliable measurements of renal hemodynamics and function by using 64-section multideteetor CT. Materials and Methods: This study was approved by the Institutional Animal Care and Use Committee. Eight pigs (two with induced unilateral renal artery stenosis) were studied with both electron-beam CT and 64-section multidetector CT at 1-week intervals in randomized order. Both kidneys were scanned repeatedly, without table movement, for about 3 minutes alter intravenous (IV) administration of a bolus of contrast medium and again during vasodilator challenge (acetylcholine). Images were reconstructed on each CT console but were analyzed on the same independent workstation. Attenuation changes in the kidneys were plotted as function of time, and time-attenuation curves (TACs) were subsequently analyzed to determine regional perfusion and volume, glomerular filtration rate (CFR), and renal blood flow (RBF). Statistical analysis utilized Student t test, analysis of variance (ANOVA), linear regression, and Bland-Alt-man analysis. Results: TACs obtained with multidetector CT were qualitatively similar to those obtained with electron-beam CT, as were the quantitative values of renal perfusion and function. RBF correlated significantly between the two techniques (RBFMD = 0.96·RBFEB mL/min; R = 0.77, P < .0). GFBMD was also similar to GFREB (77.6 ± 8.3 vs 79.8 ± 8.8 mL/min, p > .05). Bland-Altman plots showed good agreement between the two techniques. Both techniques similarly detected the differences between stenotic and contralateral kidneys. Conclusion: The clinical multidetector CT scanner provides reliable measurements of single-kidney hemodynamics and function, which are similar to those obtained with previously validated electron-beam CT. © RSNA, 2007. KW - beam KW - comparison KW - ct KW - electro KW - multidetector AU - Daghini, E AU - Primak, AN AU - Chade, AR AU - Krier, JD AU - Zhu, XY AU - Ritman, EL AU - Mccollough, CH AU - Lerman, LO PY - 2007/// UR - http://dx.doi.org/10.1148/radiol.2432060655 ER -